Sulkin began as a writer for The Late Late Show with Craig Kilborn, during the show's first three years. On the August 18, 2014 WTF podcast, he stated that he got the job after being recommended by Wellesley Wild.
Sulkin joined Family Guy in 2005, and has since produced, written and provided voices for multiple episodes, including the hour-long Star Wars homage, "Blue Harvest", as well as "Chick Cancer", "Stew-Roids", "Stu and Stewie's Excellent Adventure", "Screams of Silence: The Story of Brenda Q", "Family Guy Viewer Mail #2" (with Tom Devanney and Deepak Sethi), "Into Fat Air", Grimm Job and 3 Acts of God.
In August, 2010, Sulkin and his writing partner Wellesley Wild signed a three-year pact with 20th Century Fox TV. The two will continue working on Family Guy and also develop their own show. It is likely to be live action comedy rather than animation, although Wild said "We've been throwing around both ideas." In 2013, Sulkin and Wild produced a sitcom titled Dads, with MacFarlane as executive producer. The series was cancelled after one season.  In 2012, Sulkin co-wrote the well-received comedy Ted, along with MacFarlane and Wild.
Sulkin, along with Family Guy writers Julius Sharpe, Danny Smith, John Viener, Patrick Meighan and Seth MacFarlane were special material writers for the 85th Academy Awards, in which the latter was the host.
In March 2011, Sulkin caused a controversy by posting the following joke on Twitter: "If you wanna feel better about this earthquake in Japan, google 'Pearl Harbor death toll.'" Sulkin made the comment one day after the 2011 Tōhoku earthquake, which killed over 10,000 people in Japan. The following day, Sulkin deleted the joke and apologized, saying the post was insensitive and that he had not realized the extent and severity of the disaster.
Sulkin began dating comedian Sarah Silverman in early 2010. The pair met via Twitter, after Silverman sent him a personal message. They split up months later (October, 2010) and remain friends.
- wtf podcast
- Andreeva, Nellie (2010-08-11) 20th Century Fox TV Signs Overall Deals With 2 'Family Guy' Executive Producers Deadline Hollywood. Retrieved 2010-08-21.
- McGee, Ryan (2010-08-12) 'Family Guy' Writers Sign Three-Year Deal With Fox TV Squad. Retrieved 2010-08-21.
- Schneider, Michael (2010-08-11) Fox adopts 'Family' guys Variety. Retrieved 2010-08-21.
- Kondolojy, Amanda. "'Dads,' 'Enlisted' and 'Surviving Jack,' & 'Rake' Canceled After First Season by FOX". tvbythenumbers.zap2it.com. Tribune Digital Ventures. Retrieved 24 February 2015.
- Andersen, Soren. "'Ted': Bear comes to life, stuffed with bad behavior". The Seattle Times. Retrieved 4 July 2012.
- Alter, Alexandra (February 27, 2014). [url=http://online.wsj.com/news/articles/SB10001424052702303426304579405581525867624 "Family Guy Becomes Novelist Guy"]. Wall Street Journal. Retrieved March 18, 2014.
- Kroll, Justin (May 10, 2013). "Universal to Release Seth MacFarlane’s ‘A Million Ways To Die’ on May 30, 2014". Variety. Retrieved March 18, 2014.
- Alec Sulkin – podcast interview
- "Yesterday death toll". Retrieved 4 September 2011.
- National Post: [http://news.nationalpost.com/2011/03/14/family-guy-writer-apologizes-for-pearl-harbor-quake-joke/ ‘Family Guy’ writer apologizes for Pearl Harbor-quake joke. March 14, 2011.
- The Sunday Morning Herald: Family Guy writer sorry for Japan quake joke. March 15, 2011.
- Sulkin, Alec (2010-01-29). "Alec Sulkin: Sarah Silverman's New Boyfriend". huffingtonpost.com.
- "Alec Sulkin shares the news about his breakup with Sarah Silverman". justin.tv. Retrieved 4 September 2011.