Neldel worked as a dental assistant before she was discovered by the boss of a Berlin casting agency during a polo competition. He helped her audition for daily soap opera Gute Zeiten, schlechte Zeiten and Neldel, barely experienced in acting, immediately landed the role of Katja Wettstein. After leaving GZSZ in 1999 Neldel starred in several German motion pictures and TV films, including Lammbock, Samba in Mettmann and Emmy-winning Berlin, Berlin.
In 2005 Neldel made her breakthrough as Lisa Plenske, the leading role in the Sat.1telenovelaVerliebt in Berlin. She decided to leave the series after the final episode of season one.