Alexis Alexandris began his career where he was born and raised, in Pelopas Kiato and in 1986 played for Veria. After Veroia he moved to AEK Athens in 1991 where he won 3 consecutive championships. In 1994 Alexandris moved to Olympiacos where he had a very successful career winning 7 Greek championships and 1 Greek cup. At the sunset of his career he was also both player and manager for APOP Kinyras during the team's first participation in the Cypriot First Division.
Alexis Alexandris starting his managing career on 12 February 2008 after taking over Kerkyra FC in Second Division (Greece). He left Kerkyra after a disagreement with the clubs owner and from then moved to Olympiakos as the manager of the under21 squad.