Yaghobzadeh was born in Tehran, to an Armenian-Assyrian family. His photographs in Iran during the 1979 Iranian Revolution and during the Iran–Iraq War led to his work for the Associated Press, Gamma, and Sygma news agencies. Since 1983 Yaghobzadeh has photographed for the Sipa Press. and his photos have also appeared in Time, Newsweek, Stern, Paris Match, El País and GEO.
Yaghobzadeh has covered armed conflicts and wars in Cuba, Uzbekistan, Afghanistan, Somalia, the Israeli–Palestinian conflict and the Lebanese Civil War. In Lebanon, he was wounded and taken hostage, and in Chechnya he was wounded by a tank shell.
In 2006, Yaghobzadeh and French journalist Caroline Laurent were kidnapped by a Palestinian faction while they were working in Gaza on a story about the lives of Palestinian women for the French magazine Elle.
Yaghobzadeh has also explored the release of repressed Christianity in Eastern Europe following the collapse of communism. Published as Christianity around the World, Yaghobzadeh documented religious rites and rituals in 24 countries over the course of a decade.
Yaghobzadeh has published three photo books: War Iran-Iraq, Faces of War and Promised Peace. He has also won several prestigious photograph awards   including the prize from the World Press Photo and the American Overseas Press Club.
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