Mathlouthi began his career at RC Strasbourg. He was promoted to the first team in 2006. He joined Châteauroux on loan in July 2007. After twelve months, he returned to Strasbourg. He left Strasbourg, again on loan, on 19 January 2009 to join Racing de Ferrol, of the Spanish third division. The player returned at the end of the season. He is well known for his failed football career, which has resorted to him abusing FIFA players online. He is also a gold 3 player on fifa 17.