Aliphatic aldoxime dehydratase

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Aliphatic aldoxime dehydratase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, an aliphatic aldoxime dehydratase (EC is an enzyme that catalyzes the chemical reaction

an aliphatic aldoxime an aliphatic nitrile + H2O

Hence, this enzyme has one substrate, aliphatic aldoxime, and two products, aliphatic nitrile and H2O.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming). Other names in common use include OxdA, and aliphatic aldoxime hydro-lyase.

See also[edit]


  • Kobayashi M; Hashimoto, Y; Konishi, K; Goda, M; Noguchi, T; Higashibata, H; Kobayashi, M (2003). "Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23. Sequencing, gene expression, purification, and characterization". J. Biol. Chem. 278 (32): 29600–8. doi:10.1074/jbc.M211832200. PMID 12773527. 
  • Xie SX, Kato Y, Komeda H, Yoshida S, Asano Y (2003). "A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4". Biochemistry. 42 (41): 12056–66. doi:10.1021/bi035092u. PMID 14556637. 
  • Kato Y, Yoshida S, Xie SX, Asano Y (2004). "Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771". J. Biosci. Bioeng. 97 (4): 250–9. doi:10.1016/S1389-1723(04)70200-5. PMID 16233624.