Alkanolamines are chemical compounds that contain both hydroxyl (-OH) and amino (-NH2, -NHR, and -NR2) functional groups on an alkane backbone. The term alkanolamine is a broad class term that is sometimes used as a subclassification.
2-Aminoalcohols are an important class of organic compounds that contain both an amine and an alcohol functional groups. They are generated often by the reaction of amines with epoxides. Such compounds find a variety of industrial applications. Simple alkanolamines are used as solvents, synthetic intermediates, and high-boiling bases.
Common amino alcohols
- Aminomethyl propanol
- Methanolamine (simplest amino alcohol)
A subclass of beta blockers is often called alkanolamine beta blockers. Typical examples are:
- Veratridine and veratrine
- Tropane alkaloids such as atropine
- hormones and neurotransmitters epinephrine (adrenaline) and norepinephrine (noradrenaline)
2-Amino alcohols from amino acids
In principle, each amino acid can be hydrogenated to the corresponding 2-aminoalcohol. Examples include prolinol (from proline) and valinol (from valine). Some Example for EO Ethylene Oxide and PO Propylene oxide reaction that eventually yield Aminoalcohol. C2H4O + R-NH2 --> RNHC2H4OH [circular reference]
- Smith, Michael B.; March, Jerry (2007), Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th ed.), New York: Wiley-Interscience, ISBN 978-0-471-72091-1
- Matthias Frauenkron, Johann-Peter Melder, Günther Ruider, Roland Rossbacher, Hartmut Höke (2002). "Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a10_001.CS1 maint: Uses authors parameter (link)
- Ethylene oxide
- Propylene oxide