1980–81 All-Ireland Senior Club Hurling Championship
|Dates||1980 – 17 May 1981|
|All Ireland Champions|
|Winners||Ballyhale Shamrocks (1st win)|
|All Ireland Runners-up|
The 1980–81 All-Ireland Senior Club Hurling Championship was the 11th staging of the All-Ireland Senior Club Hurling Championship, an inter-county knockout competition for Ireland's top championship clubs representing each county. The championship was won by Ballyhale Shamrocks of Kilkenny, who beat St. Finbarr's of Cork by 1–15 to 1–11 in the final.