1980–81 All-Ireland Senior Club Hurling Championship
|Dates||12 April 1981 – 17 May 1981|
|All Ireland Champions|
|Winners||Ballyhale Shamrocks (1st win)|
|All Ireland Runners-up|
|Total Goals||10 (2.50 per game)|
|Total Points||81 (20.25 per game)|
The 1980–81 All-Ireland Senior Club Hurling Championship was the 11th season of the All-Ireland Senior Club Hurling Championship, the Gaelic Athletic Association's premier club hurling tournament. The All-Ireland series began on 12 April 1981 and ended on 17 May 1981.
|Provincial finals||All-Ireland semi-finals||All-Ireland final|
|14 December 1980 Final||Ballyhale Shamrocks||3-10 - 1-8||Coolderry||Geraldine Park|
|16 November 1980 Semi-final||Kileedy||3-7 - 3-14||St. Finbarr's||Dromcollogher Sportsfield|
|16 November 1980 Semi-final||Newmarket-on-Fergus||2-8 - 2-10||Roscrea||Newmarket-on-Fergus GAA Ground|
|30 November 1980 Final||St. Finbarr's||2-12 - 1-14||Roiscrea||Páirc Mac Gearailt|
|26 October 1980 Final||Ballycran||0-13 - 1-20||Ballycastle McQuillans||McKenna Park|
|12 April 1981 Quarter-final||McQuillan's||1-14 - 2-4||Brian Boru's||Páirc Mac Uílín|
|26 April 1981 Semi-final||McQuillan's||0-12 - 2-11||Ballyhale Shamrocks||Páirc Mac Uílín|
|26 April 1981 Semi-final||St. Finbarr's||2-11 - 1-3||Sarsfield's||Páirc Uí Chaoimh|
|17 May 1981 Final||Ballyhale Shamrocks||1-15 - 1-11||St. Finbarr's||Semple Stadium|
|Referee: N O'Donoghue (Dublin)
- McQuillan's of Antrim become the first team to win three successive Ulster titles.
- Ballyhale Shamrocks win the All-Ireland title for the first time. In doing so they deny St. Finbarr's a unique double as their Gaelic footballers would later claim the All-Ireland title in that code.
- Ní Fhlatharta, Bernie (20 August 2013). "1980 change of luck was all down to Pope John Paul II". Connacht Tribune. Retrieved 24 July 2015.
- Foley, Cliona (1 December 2009). "'Cha' signals Ballyhale's ambition for famous five". Irish Independent. Retrieved 25 July 2015.
- "Teams stand on brink of history". Kilkenny People. 11 March 2010. Retrieved 25 July 2015.
- "Young club still has long tradition of success". Irish Times. 28 November 2008. Retrieved 25 July 2015.