Allan Bradley

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Allan Bradley
Professor Sir Allan Bradley, Founder & Chief Scientific Officer at the launch of the Shakespeare Review (8740129867).jpg
Allan Bradley at the launch of the Shakespeare review, organised by Policy Exchange
Born Allan Bradley
Alma mater University of Cambridge (BA, MA, PhD)[1]
Known for Embryonic stem cells[2]
Awards
Scientific career
Fields Mouse genomics[4][5][6][7][8]
Institutions
Thesis Isolation characterisation and developmental potential of murine embryo-derived stem cells (1986)
Doctoral advisor Martin Evans[9][10]
Website sanger.ac.uk/research/faculty/abradley

Allan Bradley FRS is a British geneticist at the Wellcome Trust Sanger Institute.[11][12][13][14]

Education[edit]

Bradley was educated at the University of Cambridge where he earned Bachelor of Arts, Master of Arts and PhD[15] degrees in Genetics from Trinity College, Cambridge gained while working in the laboratory of Martin Evans.[1][9]

Career[edit]

Following his PhD, Bradley was appointed Assistant Professor at Baylor College of Medicine, beginning in 1987 where he was also a Searle Scholar in 1988.[16] Bradley was appointed a Howard Hughes Medical Institute Investigator in 1993 and director of the Wellcome Trust Sanger Institute, from October 2000 (preceded by John Sulston) to April 2010, succeeded by Michael Stratton.

Awards and honours[edit]

Bradley won a 1994 DeBakey Award[17] and was elected a Fellow of the Royal Society (FRS) in 2002. His certificate of election reads:

"Allan Bradley has made important contributions to the technique of mutation of endogenous genes in mice, an approach that has opened up a new era of research in biology. It is impossible to open an issue of a major journal nowadays without coming across an article that describes the consequences of mutating an endogenous gene in mice. The generation of these mice is based on concepts and techniques that can be traced back to experiments performed and published by Bradley fifteen years ago. In the years since, he has not only used ES cell technology to provide key information on the functions of many genes including several important tumour suppressor genes, but has also continued to improve and develop the techniques, technology, and tools for genetic manipulation in the mouse. Today, mice can be generated with changes as subtle as an alteration in a single nucleotide or as extensive as the deletion of millions of base pairs. These alterations will gain increasing importance in genetic experiments aimed at understanding the function of genes in the mammalian genome in the post genome era."[2]

References[edit]

  1. ^ a b BRADLEY, Prof. Allan. ukwhoswho.com. Who's Who. 2014 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc.  closed access publication – behind paywall (subscription required)
  2. ^ a b "Certificate of election EC/2002/01: Allan Bradley". London: The Royal Society. Archived from the original on 2015-08-05. Retrieved 2013-11-14. 
  3. ^ "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 2015-03-16. 
  4. ^ Donehower, L. A.; Harvey, M.; Slagle, B. L.; McArthur, M. J.; Montgomery Jr, C. A.; Butel, J. S.; Bradley, A. (1992). "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours". Nature. 356 (6366): 215–221. doi:10.1038/356215a0. PMID 1552940. 
  5. ^ Dalton, D.; Pitts-Meek, S.; Keshav, S.; Figari, I.; Bradley, A.; Stewart, T. (1993). "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes". Science. 259 (5102): 1739–1742. doi:10.1126/science.8456300. PMID 8456300. 
  6. ^ Guo, G.; Wang, W.; Bradley, A. (2004). "Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells". Nature. 429 (6994): 891–895. doi:10.1038/nature02653. PMID 15215866. 
  7. ^ Kile, B. T.; Hentges, K. E.; Clark, A. T.; Nakamura, H.; Salinger, A. P.; Liu, B.; Box, N.; Stockton, D. W.; Johnson, R. L.; Behringer, R. R.; Bradley, A.; Justice, M. J. (2003). "Functional genetic analysis of mouse chromosome 11". Nature. 425 (6953): 81–86. doi:10.1038/nature01865. PMID 12955145. 
  8. ^ "Mouse genomics – Allan Bradley laboratory". Wellcome Trust Sanger Institute. Archived from the original on 2010-04-01. 
  9. ^ a b "Allan Bradley – Wellcome Trust Sanger Institute". Sanger.ac.uk. Archived from the original on 2013-11-13. 
  10. ^ Watts, Geoff (2007). "Martin Evans: joint winner of 2007 Nobel Prize in medicine". The Lancet. 370 (9605): 2095. doi:10.1016/S0140-6736(07)61889-3. ISSN 0140-6736. PMID 18156018. 
  11. ^ "Professor Allan Bradley: a decade at Sanger | Wellcome Trust". Wellcome.ac.uk. 15 June 2010. Retrieved 2012-04-04. 
  12. ^ "Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society – Wellcome Trust Sanger Institute". Sanger.ac.uk. Retrieved 2012-04-04. 
  13. ^ Allan Bradley's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  14. ^ Kate Kelland (12 October 2011). "New stem cell method could end need for liver transplants". National Post. 
  15. ^ Bradley, A. (1985). Isolation characterization and developmental potential of murine embryo-derived stem cells (PhD thesis). University of Cambridge. 
  16. ^ "Searle Scholars Program: Allan Bradley (1988)". Searlescholars.net. Retrieved 2012-04-04. 
  17. ^ "Bradley – DeBakey Excellence in Research Awards- Baylor College of Medicine, Houston, Texas". Bcm.edu. Archived from the original on 2012-07-19. Retrieved 2012-04-04. 
Non-profit organization positions
Preceded by
John Sulston
Director of the Wellcome Trust Sanger Institute
2000–2010
Succeeded by
Michael Stratton