Nuzi was probably trained in Fabriano by local masters, including the so-called Master of Campodonico. Documents verify his presence in Florence in 1346, where he would have encountered works by Giotto and his followers. His style has been characterized as Giottesque and Sienese. Nuzi primarily worked under commissions for churches, producing religious-themed works.
In Fabriano, his masterwork are the frescoes in the Chapel of Sant’Orsola in the church of Santa Lucia. He also painted some wooden statues now in the Pinacoteca Civica di Bruno Molajoli in Fabriano.
There are 2 devotional theme paintings by Allegretto Nuzi in the Museum of Fine Arts,Houston,Texas.("Saints and Angels)There is another devotional theme painting by this Late Medieval Italian painter in the Detroit Institute of Art in Detroit,Michigan("Madonna and Child With Saints and Angels,Crucifixion,Nativity").