|Traded as||NYSE: AGN
S&P 500 Component
|Industry||Branded and generic pharmaceuticals, and pharmaceutical research and development.|
|Founded||Libertyville, Illinois, United States (Spring 1984)|
|Founder||Allen Chao, Ph.D. and David Hsia, Ph.D.|
|Headquarters||Dublin, Ireland and Parsippany-Troy Hills, New Jersey, United States.|
Number of locations
|40 manufacturing facilities, 27 global R&D centers and marketing/sales facilities worldwide.|
|Paul Bisaro, Executive Chairman, Brenton L. Saunders President and CEO|
|Products||Branded and generic pharmaceuticals|
|Revenue||US$ 4.2 billion(Q1 2015) |
|US$ 1.090 billion (2014)|
|-US$ 1.630 billion (2014)|
|Total assets||US$ 6.881 billion (2014)|
|Total equity||US$ 28.335 billion (2014)|
Number of employees
|30,000 (June 2015)|
- 1 Profile
- 2 History
- 3 Company evolution
- 4 Safety reports
- 5 Key Products
- 6 References
- 7 External links
Allergan, plc (NYSE: AGN) is a global pharmaceutical company focused on developing, manufacturing and commercializing branded pharmaceuticals, generic and over-the-counter medicines, and biologic products. Allergan has a commercial presence across approximately 100 countries. The company has global headquarters in Dublin, Ireland and administrative headquarters in Parsippany-Troy Hills, New Jersey, United States.
Allergan markets a portfolio of brand products in key therapeutic categories including: Aesthetics/Dermatology/Plastic Surgery; Neurosciences/CNS; Eye Care; Women’s Health and Urology; GI and Cystic Fibrosis; and Cardiovascular Disease and Infectious Disease. The company's product portfolio includes Botox, Namenda, Restasis, Linzess, Bystolic, Juvederm, Latisse, Lo Loestrin Fe, Estrace, Teflaro, Dalvance, Ozurdex, Optive, Natrelle, Viibryd, Liletta, Saphris, Enablex, Actonel, Androderm, Gelnique and others.
Allergan also operates the world's third-largest generics business and has more than 40 manufacturing and distribution facilities around the world, with a capacity of approximately 40 billion units annually. Allergan Global Operations also includes Anda, Inc., the fourth-largest U.S. generic pharmaceutical product distributor in the United States.
Allergan is also developing biosimilars products in oncology and other therapeutic categories, and currently has a portfolio of five biosimilar products in development.
The company was founded in the spring of 1983, as Watson Pharmaceuticals, Inc. With funding from friends and family, colleagues Allen Chao, Ph.D. and David Hsia, Ph.D., began a small drug development enterprise. Just two months later, the founders established an initial product development and analytical laboratory with six employees (including both founders) in a leased space in Libertyville, Illinois.
By late fall of the same year, the company moved to Southern California into an initial 2,000-square-foot (190 m2) leased facility in Corona, and the development and manufacturing of generic pharmaceuticals began. The Corona site became the corporate headquarters for the rapidly expanding U.S. company.
Throughout its history, Allergan has expanded both organically and as the result of strategic acquisitions that brought broader product lines, enhanced drug delivery technologies, and ultimately branded pharmaceutical products to the company. In 1993, Allergan, then Watson, announced its initial public offering (IPO) of shares of common stock. The company was initially listed on the NASDAQ under the ticker symbol WATS. The company moved to the New York Stock Exchange (NYSE) in 1997, and began trading under the symbol WPI.
2000 to 2009
In 2000, the company acquired Schein Pharmaceutical, Inc., an acquisition that more than doubled the company’s size. In that same year, the group reported revenues in excess of $1 billion. In the fall of 2006, it acquired Andrx Corporation, a Fort Lauderdale, FL–based pharmaceutical company, making it the third largest specialty pharmaceutical company based on total prescriptions dispensed. In 2007, Dr. Allen Chao retired as President and Chief Executive Officer (CEO) and was succeeded by Paul M. Bisaro. The company’s international presence began with the acquisition of the Arrow Group in 2009, providing the company with commercial presence in more than 20 international markets. As a result of the Arrow acquisition, the company also acquired the biopharmaceutical development organization Eden Biodesign in Liverpool, UK.
2011 to 2014
In 2011, the company moved its corporate headquarters from Corona, California to Parsippany, New Jersey. The new LEED-certified corporate headquarters at the Morris Corporate Center in Parsippany was formally dedicated on June 9, 2011.
Actavis Acquisition and Watson Name Change
In November 2012, Watson acquired the Switzerland-based, global generics company Actavis Group for EUR4.25 billion, creating the world’s third largest generics company, with a leading position in key established commercial markets including the U.S., UK, Nordics, Canada, Australia, and emerging markets in Central and Eastern Europe, and Russia. Following the acquisition, Watson adopted Actavis' name for its global operations.
On March 1, 2013, the company acquired MAP Pharmaceuticals Inc., a development-stage company mainly researching the treatment of migraine and other oral drugs in Neurology for approximately $958 million. The principal products of this sub-company are under review with the US Food and Drug Administration (FDA).
Warner Chilcott plc Acquisition
On October 1, 2013 Actavis acquired Irish pharmaceutical company Warner Chilcott plc (previously known as Galen) in a stock-for-stock transaction valued at approximately $8.5 billion. The combination created a company with approximately $10 billion in anticipated combined annual 2013 revenue, and the third-largest U.S. specialty pharmaceutical company with approximately $3 billion in annual revenue focused on the core therapeutic categories of women’s health, urology, gastroenterology and dermatology. In association with the merger the company relocated its corporate headquarters to Ireland while maintaining its operational headquarters in Parsippany, taking advantage of the lower (17% vs. 35% in the United States) Irish corporate tax rate. This deal inspired a series of similar moves by other drug companies and led to new Treasury Department regulations limiting the ability of companies to perform such inversions, although Actavis was exempt from these regulations as its move abroad had already been completed. CEO Paul Bisaro stated that in making the inversion, they were trying to "level the playing field" given the high corporate tax rate in the United States.
Forest Laboratories Acquisition
On July 1, 2014 Actavis announced that it had completed its acquisition of Forest Laboratories (who previously acquired, Furiex Pharmaceuticals Inc and Aptalis Pharma) in a cash and equity transaction valued at approximately $25 billion. Following the acquisition, the company restructured its executive leadership, with Paul Bisaro being named Executive Chairman, and Brent Saunders being appointed CEO and President of the combined organization.
2015 to the present day
In June 2015 Allergan announced it would acquire Kythera Biopharmaceuticals for around $2.1 billion. On June 1, the company completed its acquisition of Auden Mckenzie Holdings Limited for £306 million.
Allergan Acquisition and Actavis Name Change
In November 2014 Actavis announced its intention to acquire Allergan, the manufacturer of Botox Completion of the deal would increase its market capitalization to $147 billion. On March 17, 2015, Actavis completed the acquisition of Allergan in a cash and equity transaction valued at approximately $70.5 billion. The combination created a $23 billion diversified global pharmaceutical company with commercial reach across 100 countries. In June 2015, Actavis officially changed its name to Allergan.
The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):
(formerly known as Actavis until June 2015
when it adopted Allergans name)
In 2011, FDA reported issues in the investigation of safety of silicone gel-filled breast implants. However, the company announced later the reassurance to patients of the safety and exclusion of its drugs from the investigated breast implant devices, stating that all of its products are above safety standards around the world.
In December 2013, the company sold its obesity intervention business to Apollo Endosurgery, Inc., for a cash payment of $75 million and a $15 million minority equity interest in Apollo Endosurgery.
The use of infant foreskin fibroblast in products
- Actonel (risedronic acid) for the treatment or prevention osteoporosis, and for Paget's disease of bone treatment
- Acuvail (ketorolac ophthalmic solution) for the treatment of pain and inflammation following cataract surgery
- Aczone (dapsone gel) for acne
- Alphagan P (brimonidine ophthalmic solution) for glaucoma
- Androderm CIII (testosterone transdermal system) for replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone
- Asacol HD (mesalamine extended release) for moderately active ulcerative colitis
- Atelvia (risedronic acid delayed release) for the treatment of osteoporosis in postmenopausal women
- Avycaz (ceftazidime/avibactam) for complicated intra-abdominal infections (in combination with metronidazole)
- Botox (onabotulinumtoxinA) for various spasms and dystonias
- Botox Cosmetic/Vistabel (onabotulinumtoxinA)—anti-wrinkle cosmetic drug derived from Botox
- Bystolic (nebivolol) for hypertension
- Combigan (brimonidine/timolol) for glaucoma
- Crinone (progesterone gel) for progesterone supplementation or replacement as part of an assisted reproductive technology (ART) treatment for infertile women with progesterone deficiency
- Dalvance (dalbavancin) for acute bacterial skin and skin structure infections (ABSSSI)
- Delzicol (mesalamine extended release) for mildly-to-moderately active ulcerative colitis
- Doryx (doxycycline hyclate extended release)—a tetracycline-class antimicrobial
- Enablex (darifenacin extended release) for overactive bladder
- Estrace (estradiol vaginal cream) for vulvar and vaginal atrophy due to menopause
- Fetzima (levomilnacipran extended release) for major depressive disorder
- Gelnique (oxybutynin gel) for overactive bladder
- Juvéderm injectable gel (cross-linked hyaluronic acid)—dermal filler
- Lastacaft (alcaftadine ophthalmic solution) for the prevention of itching associated with eye allergies
- Latisse (bimatoprost ophthalmic solution) for hypotrichosis of the eyelashes
- Liletta (levonorgestrel-releasing intrauterine system) for contraception
- Linzess (linaclotide) for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation—co-marketed with Ironwood Pharmaceuticals
- Lo Loestrin Fe (norethindrone and ethinyl estradiol; ethinyl estradiol; ferrous fumarate) for contraception
- Lumigan (bimatoprost ophthalmic solution) for glaucoma
- Namenda (memantine) for moderate-to-severe dementia of the Alzheimer's type
- Namenda XR (memantine extended release) for moderate-to-severe Alzheimer's disease
- Namzaric (memantine extended release/donepezil) for moderate-to severe-Alzheimer's disease in patients who are currently taking and can continue to take certain doses of both Namenda or Namenda XR (see above) and donepezil
- Natrelle—breast implants (silicone and saline)
- Ozurdex (dexamethasone intravitreal implant) for branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO)
- Orbera system—an intragastric balloon, inserted endoscopically; designed to assist weight loss by partially filling the stomach and inducing satiety for overweight patients with a body mass index (BMI) of 27 or greater
- Rapaflo (silodosin) for benign prostatic hyperplasia
- Restasis (ciclosporin ophthalmic emulsion) for dry eye syndrome
- Saphris (asenapine sublingual tablets) for schizophrenia and bipolar I disorder
- Skinmedica—facial line
- Teflaro (ceftaroline fosamil) for community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI)
- Viberzi (eluxadoline) for diarrhea-predominant irritable bowel syndrome (IBS-D)
- Viibryd (vilazodone) for major depressive disorder
- Zenpep (pancrelipase) for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, or other conditions
- TheStreet Transcripts. "Actavis (ACT) Earnings Report: Q1 2015 Conference Call Transcript". The Street.
- "Actavis plc". MarketWatch.
- "Form 10K". Actavis plc.
- "Botox cosmetics". Allergan.
- "Restasis" (PDF). Allergan.
- "Bystolic". Actavis.
- "Juvederm". Allergan.
- "Latisse" (PDF). Allergan.
- "Ozurdex". Allergan.
- "Optive". Allergan.
- "Natrelle". Allergan.
- "Actavis Confirms Favorable Ruling In Generic Pulmicort Respules Patent Suit". First Word Pharma.
- John Carroll. "Can Actavis deliver a promised $6B boost from this pipeline". Fierce Biotech.
- "Actavis Adopting Allergan Name; Earnings Soar as Closing of Deal Looms". WSJ. 2015-02-18. Retrieved 2015-02-19.
- "Actavis Changes Name to Allergan After Deal For Botox Maker". WSJ. 2015-06-15. Retrieved 2015-06-15.
- "ACT Profile - Actavis plc Ordinary Shares Stock - Yahoo! Finance". yahoo.com.
- "Watson Pharmaceuticals acquired Arrow Group for 1.75B". TBI.
- "Watson Pharmaceuticals agrees to buy a rival". NY Times.
- "WATSON PHARMACEUTICALS TO BUY ANDRX CORP". PharmacyTimes.com.
- "Watson Pharmaceuticals, Inc. Says CEO to Retire, Names Replacement". Fierce Biotech.
- Shannon Pettypiece. "Watson Agrees to Buy Arrow Group for $1.75 Billion". Bloomberg.
- Gareth Macdonald. "Watson buys Eden Biodesign". Biopharma-Reporter.com.
- "Generic drug maker Watson opening research operations in North Brunswick". NJ.com.
- Eyk Henning. "Watson, Actavis to Merge in €4.5 Billion Deal". Wall Street Journal.
- "Allergan, Inc.: quotes & news - Google Finance". google.com.
- "News - Actavis". Actavis.
- "Actavis to Buy Warner Chilcott in $5 Billion Deal". The Wall Street Journal.
- "Allergan Escapes Valeant’s Pursuit, Agreeing to Be Bought by Actavis". The New York Times.
- Drew Armstrong. "Actavis Lowers Tax Rate to 17% After Warner Chilcott Deal". Bloomberg.com.
- "Actavis to buy Forest Laboratories for 25 billion". Bloomberg.
- "GEN - News Highlights:Actavis Deal's a Dandy for Activist Icahn". GEN.
- "Allergan to Acquire Kythera for $2.1B". GEN.
- "BBC News - Actavis to buy Botox-maker Allergan $66bn". BBC News.
- Caroline Chen. "Actavis Surges to Top Drugmaker Ranks With Acquisitions". Bloomberg.com.
- "The Morning Ledger: Actavis Could Again Evade Treasury’s Grasp for Post-Inversion Tax Break". WSJ.
- "Actavis plc is now Allergan plc". Retrieved 16 June 2015.
- "Allergan - Allergan Reassures Patients and Surgeons of the Quality and Safety of Its Breast Implant Devices Sold and Distributed Worldwide". shareholder.com.
- "Allergan, Inc. Completes Sale of Obesity Intervention Business".
- Bronstein, Phil (18 July 2011). "What's in a face? You'd be surprised". SFGate. Retrieved 13 May 2015.