Alnespirone

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Alnespirone
Alnespirone.svg
Systematic (IUPAC) name
(+)-4-dihydro-2H-chromen-3-yl]-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
Identifiers
CAS Number 143413-68-7 YesY
ATC code none
PubChem CID 178132
ChemSpider 8002134 YesY
UNII 34E28BM822 YesY
ChEMBL CHEMBL2104091
Chemical data
Formula C26H38N2O4
Molar mass 442.589 g/mol
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Alnespirone (S-20,499) is a selective 5-HT1A receptor full agonist of the azapirone chemical class.[1][2][3] It has antidepressant and anxiolytic effects.[1]

See also[edit]

References[edit]

  1. ^ a b Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J (1992). "Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.". Neuroreport. 3 (1): 84–86. doi:10.1097/00001756-199201000-00022. PMID 1351756. 
  2. ^ Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J (1992). "5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.". Psychopharmacology (Berl). 108 (1-2): 47–50. doi:10.1007/BF02245284. PMID 1357709. 
  3. ^ Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G (2003). "In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.". Eur J Pharmacol. 459 (1): 17–26. doi:10.1016/S0014-2999(02)02814-5. PMID 12505530.