Aloe emodin

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Aloe emodin
Aloe emodin.svg
Clinical data
Routes of
administration
Oral
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.006.884
Chemical and physical data
Formula C15H10O5
Molar mass 270.24 g/mol
3D model (JSmol)
Melting point 223 to 224 °C (433 to 435 °F) Sublimes in CO2 stream
 NYesY (what is this?)  (verify)

Aloe emodin (1,3,8-trihydroxyanthraquinone) is an anthraquinone and a variety of emodin present in aloe latex, an exudate from the aloe plant. It has a strong stimulant-laxative action.[1] Aloe emodin is not carcinogenic when applied to the skin, although it may increase the carcinogenicity of some kind of radiation.[2][3]

Aloe emodin is found in the gel, sap or leaves of Aloe vera, the socotrine aloe, Barbados aloe, and Zanzibar aloes, the bark of Frangula (Rhamnus frangula) and Cascara Sagrada (Rhamnus purshiana), the leaves of Senna (Cassia angustifolia), and the rhizome of Rhubarb (Rheum rhaponticum).[citation needed] Aloe-emodin has not been found in Natal aloes.[citation needed] It has a marked anti-viral effect in vitro against both herpes simplex virus (HSV) type 1 and 2.[4]

References[edit]

  1. ^ The Merck Index, 12th Edition. 313
  2. ^ Badgwell, DB; Walker, CM; Baker, WT; Strickland, FM (2004). "Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors". Molecular carcinogenesis. 39 (3): 127–38. PMID 14991742. doi:10.1002/mc.10170. 
  3. ^ National Toxicology, Program (2010). "Photocarcinogenesis study of aloe vera CAS NO. 481-72-1(Aloe-emodin) in SKH-1 mice (simulated solar light and topical application study)". National Toxicology Program technical report series (553): 7–33, 35–97, 99–103 passim. PMID 21031007. 
  4. ^ http://www.google.com/patents/US4670265 Aloe emodin and other anthraquinones and anthraquinone-like compounds from plants virucidal against herpes simplex viruses

See also[edit]