Alopecia totalis is the loss of all head hair. Its causes are unclear, but believed to be autoimmune. Stress is thought to be a contributor in alopecia areata. However, many with the disorder lead relatively low stress lives.
Scalp cooling has specifically been used to prevent alopecia in docetaxel chemotherapy, although it has been found prophylactic in other regimens as well. Treatment effects may take time to resolve, with one study showing breast cancer survivors wearing wigs up to 2 years after chemotherapy.
^Joly, Pascal (2006). "The use of methtrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis". Journal of the American Academy of Dermatology55 (4): 632–6. doi:10.1016/j.jaad.2005.09.010. PMID17010743.
^Hurk, C. J. G.; Breed, W. P. M.; Nortier, J. W. R. (2012). "Short post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia". Supportive Care in Cancer20 (12): 3255–3260. doi:10.1007/s00520-012-1465-0. PMID22539051.
^Lemieux, J. (2012). "Reducing chemotherapy-induced alopecia with scalp cooling". Clinical advances in hematology & oncology : H&O10 (10): 681–682. PMID23187775.
^Van Den Hurk, C. J.; Peerbooms, M.; Van De Poll-Franse, L. V.; Nortier, J. W.; Coebergh, J. W. W.; Breed, W. P. (2012). "Scalp cooling for hair preservation and associated characteristics in 1411 chemotherapy patients - Results of the Dutch Scalp Cooling Registry". Acta Oncologica51 (4): 497–504. doi:10.3109/0284186X.2012.658966. PMID22304489.
^Oshima, Y.; Watanabe, T.; Nakagawa, S.; Endo, A.; Shiga, C. (2012). "A questionnaire survey about hair loss after chemotherapy for breast cancer". Gan to kagaku ryoho. Cancer & chemotherapy39 (9): 1375–1378. PMID22996772.