Alpha-1B adrenergic receptor

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Adrenoceptor alpha 1B
External IDs OMIM104220 MGI104774 HomoloGene55477 IUPHAR: 23 ChEMBL: 232 GeneCards: ADRA1B Gene
RNA expression pattern
PBB GE ADRA1B 207589 at tn.png
More reference expression data
Species Human Mouse
Entrez 147 11548
Ensembl ENSG00000170214 ENSMUSG00000050541
UniProt P35368 P97717
RefSeq (mRNA) NM_000679 NM_001284380
RefSeq (protein) NP_000670 NP_001271309
Location (UCSC) Chr 5:
159.92 – 159.97 Mb
Chr 11:
43.77 – 43.9 Mb
PubMed search [1] [2]

The alpha-1B adrenergic receptor1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[1]


There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.


This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.[1]




Alpha-1B adrenergic receptor has been shown to interact with AP2M1.[3] A role in regulation of dopaminergic neurotransmission has also been suggested.[4][5]

See also[edit]


  1. ^ a b "Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor". 
  2. ^ Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE (2002). "Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist". Br. J. Pharmacol. 136 (5): 701–8. doi:10.1038/sj.bjp.0704773. PMC 1573401. PMID 12086979. 
  3. ^ Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451. 
  4. ^ Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (April 2002). "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates". J. Neurosci. 22 (7): 2873–84. PMID 11923452. 
  5. ^ Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (December 2004). "5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants". Eur. J. Neurosci. 20 (11): 3073–84. doi:10.1111/j.1460-9568.2004.03805.x. PMID 15579162. 

Further reading[edit]

  • Ramarao CS, Denker JM, Perez DM; et al. (1992). "Genomic organization and expression of the human alpha 1B-adrenergic receptor.". J. Biol. Chem. 267 (30): 21936–45. PMID 1328250. 
  • Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S (1992). "G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354–8. doi:10.1073/pnas.88.24.11354. PMC 53133. PMID 1662393. 
  • Lomasney JW, Cotecchia S, Lorenz W; et al. (1991). "Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5". J. Biol. Chem. 266 (10): 6365–9. PMID 1706716. 
  • Yang-Feng TL, Xue FY, Zhong WW; et al. (1990). "Chromosomal organization of adrenergic receptor genes". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. doi:10.1073/pnas.87.4.1516. PMC 53506. PMID 2154750. 
  • Schwinn DA, Johnston GI, Page SO; et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325. 
  • Weinberg DH, Trivedi P, Tan CP; et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. doi:10.1006/bbrc.1994.1845. PMID 8024574. 
  • Forray C, Bard JA, Wetzel JM; et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249. 
  • Diviani D, Lattion AL, Larbi N; et al. (1996). "Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 271 (9): 5049–58. doi:10.1074/jbc.271.9.5049. PMID 8617782. 
  • Diviani D, Lattion AL, Cotecchia S (1997). "Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 272 (45): 28712–9. doi:10.1074/jbc.272.45.28712. PMID 9353340. 
  • Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484. 
  • Sasaguri T, Teruya H, Ishida A; et al. (2000). "Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells". Biochem. Biophys. Res. Commun. 268 (1): 25–30. doi:10.1006/bbrc.1999.2066. PMID 10652206. 
  • Minneman KP, Lee D, Zhong H; et al. (2000). "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes". J. Neurochem. 74 (6): 2392–400. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200. 
  • Shibata K, Katsuma S, Koshimizu T; et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310. 
  • Diviani D, Lattion AL, Abuin L; et al. (2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451. 
  • Gonzalez-Cabrera PJ, Gaivin RJ, Yun J; et al. (2003). "Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130". Mol. Pharmacol. 63 (5): 1104–16. doi:10.1124/mol.63.5.1104. PMID 12695539. 
  • Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. doi:10.1081/RRS-120025200. PMID 14626446. 
  • Hague C, Uberti MA, Chen Z; et al. (2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. doi:10.1074/jbc.M314014200. PMID 14736874. 
  • Kang SK, Yi KS, Kwon NS; et al. (2004). "Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200. PMID 15220331. 
  • Gonzalez-Cabrera PJ, Shi T, Yun J; et al. (2004). "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology 145 (11): 5157–67. doi:10.1210/en.2004-0728. PMID 15297446. 
  • Zhang T, Xu Q, Chen FR; et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470.