Alpha-1D adrenergic receptor

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Adrenoceptor alpha 1D
Symbols ADRA1D ; ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2
External IDs OMIM104219 MGI106673 HomoloGene551 IUPHAR: 24 ChEMBL: 223 GeneCards: ADRA1D Gene
RNA expression pattern
PBB GE ADRA1D 210961 s at tn.png
PBB GE ADRA1D 210960 at tn.png
More reference expression data
Species Human Mouse
Entrez 146 11550
Ensembl ENSG00000171873 ENSMUSG00000027335
UniProt P25100 A2ANQ2
RefSeq (mRNA) NM_000678 NM_013460
RefSeq (protein) NP_000669 NP_038488
Location (UCSC) Chr 20:
4.22 – 4.25 Mb
Chr 2:
131.55 – 131.56 Mb
PubMed search [1] [2]

The alpha-1D adrenergic receptor1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[1]


There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.


This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.[1]



See also[edit]


  1. ^ a b "Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor". 
  2. ^ Buckner SA, Milicic I, Daza A, Lynch JJ, Kolasa T, Nakane M, Sullivan JP, Brioni JD (2001). "A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity". Eur. J. Pharmacol. 433 (1): 123–7. doi:10.1016/s0014-2999(01)01519-9. PMID 11755142. 
  3. ^ Cleary L, Murad K, Bexis S, Docherty JR (2005). "The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist". Auton Autacoid Pharmacol 25 (4): 135–41. doi:10.1111/j.1474-8673.2005.00342.x. PMID 16176444. 

Further reading[edit]

  • Schwinn DA, Lomasney JW (1992). "Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype.". Eur. J. Pharmacol. 227 (4): 433–6. doi:10.1016/0922-4106(92)90162-O. PMID 1359975. 
  • Bruno JF, Whittaker J, Song JF, Berelowitz M (1991). "Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor.". Biochem. Biophys. Res. Commun. 179 (3): 1485–90. doi:10.1016/0006-291X(91)91740-4. PMID 1656955. 
  • Esbenshade TA, Hirasawa A, Tsujimoto G; et al. (1995). "Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.". Mol. Pharmacol. 47 (5): 977–85. PMID 7746284. 
  • Schwinn DA, Johnston GI, Page SO; et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325. 
  • Weinberg DH, Trivedi P, Tan CP; et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. doi:10.1006/bbrc.1994.1845. PMID 8024574. 
  • Loftus SK, Shiang R, Warrington JA; et al. (1994). "Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5.". Cytogenet. Cell Genet. 67 (2): 69–74. doi:10.1159/000133802. PMID 8039425. 
  • Yang-Feng TL, Han H, Lomasney JW, Caron MG (1994). "Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13.". Cytogenet. Cell Genet. 66 (3): 170–1. doi:10.1159/000133693. PMID 8125015. 
  • Forray C, Bard JA, Wetzel JM; et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249. 
  • Minneman KP, Lee D, Zhong H; et al. (2000). "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.". J. Neurochem. 74 (6): 2392–400. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200. 
  • Keffel S, Alexandrov A, Goepel M, Michel MC (2000). "alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells.". Biochem. Biophys. Res. Commun. 272 (3): 906–11. doi:10.1006/bbrc.2000.2850. PMID 10860850. 
  • Kyprianou N, Benning CM (2000). "Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis.". Cancer Res. 60 (16): 4550–5. PMID 10969806. 
  • Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Shibata K, Katsuma S, Koshimizu T; et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310. 
  • Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. doi:10.1081/RRS-120025200. PMID 14626446. 
  • Hague C, Uberti MA, Chen Z; et al. (2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. doi:10.1074/jbc.M314014200. PMID 14736874. 
  • Gonzalez-Cabrera PJ, Shi T, Yun J; et al. (2004). "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology 145 (11): 5157–67. doi:10.1210/en.2004-0728. PMID 15297446. 
  • Zhang T, Xu Q, Chen FR; et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470. 
  • Sigala S, Dellabella M, Milanese G; et al. (2005). "Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter". Neurourol. Urodyn. 24 (2): 142–8. doi:10.1002/nau.20097. PMID 15690361. 
  • Chen Z, Hague C, Hall RA, Minneman KP (2006). "Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction". J. Biol. Chem. 281 (18): 12414–20. doi:10.1074/jbc.M508651200. PMID 16533813. 
  • Michelotti GA, Brinkley DM, Morris DP; et al. (2007). "Epigenetic regulation of human α1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation". FASEB J. 21 (9): 1979–93. doi:10.1096/fj.06-7118com. PMC 2279228. PMID 17384146.