Α-Hydroxyglutaric acid

α-Hydroxyglutaric acid

Names
IUPAC name 2-Hydroxypentanedioic acid
Other names 2-Hydroxyglutaric acid
Identifiers
CAS Number	2889-31-8 N
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:17084 Y
ChemSpider	42 Y
KEGG	C02630 Y
MeSH	Alpha-hydroxyglutarate
PubChem CID	43
CompTox Dashboard (EPA)	DTXSID40864360
InChI InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10) Y Key: HWXBTNAVRSUOJR-UHFFFAOYSA-N Y InChI=1/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10) Key: HWXBTNAVRSUOJR-UHFFFAOYAI
SMILES C(CC(=O)O)C(C(=O)O)O O=C(O)C(O)CCC(=O)O
Properties
Chemical formula	C5H8O5
Molar mass	148.114 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

α-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-hydroxyglutaric aciduria.