Alpha-taxilin

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TXLNA
Identifiers
Aliases TXLNA, IL14, TXLN, IL-14, taxilin alpha
External IDs MGI: 105968 HomoloGene: 14062 GeneCards: TXLNA
RNA expression pattern
PBB GE TXLNA 212300 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_175852

NM_001005506
NM_001199695

RefSeq (protein)

NP_787048

NP_001005506.2
NP_001186624.1

Location (UCSC) Chr 1: 32.18 – 32.2 Mb Chr 4: 129.63 – 129.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.[3][4][5]

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells.[6] This molecule was also recently designated taxilin.[7] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Gene[edit]

In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.[8] The il14 locus is near the gene for LCK on chromosome 1 in humans.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072. 
  4. ^ Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. doi:10.1016/j.bbrc.2003.10.069. PMID 14623251. 
  5. ^ "Entrez Gene: TXLNA taxilin alpha". 
  6. ^ Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. doi:10.1073/pnas.90.13.6330. PMC 46922Freely accessible. PMID 8327514. 
  7. ^ Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells. 8 (1): 17–28. doi:10.1046/j.1365-2443.2003.00612.x. PMID 12558796. 
  8. ^ Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. PMID 17015757. 

External links[edit]

Further reading[edit]