Alpha 1-antichymotrypsin

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SERPINA3
PBB Protein SERPINA3 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SERPINA3, AACT, ACT, GIG24, GIG25, serpin family A member 3
External IDs MGI: 98377 HomoloGene: 111129 GeneCards: 12
RNA expression pattern
PBB GE SERPINA3 202376 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001085

NM_011458

RefSeq (protein)

NP_001076.2

NP_035588.2

Location (UCSC) Chr 14: 94.59 – 94.62 Mb Chr 12: 104.34 – 104.35 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alpha 1-antichymotrypsin (α1AC)[1] is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene.

Function[edit]

Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.[2]

This protein is produced in the liver, and is an acute phase protein that is induced during inflammation.

Clinical significance[edit]

Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.[3]

Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.[2]

Interactions[edit]

Alpha 1-antichymotrypsin has been shown to interact with DNAJC1.[4]

References[edit]

  1. ^ Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 0-397-54589-4. 
  2. ^ a b Kalsheker N (1996). "Alpha 1-antichymotrypsin". Int. J. Biochem. Cell Biol. 28 (9): 961–4. doi:10.1016/1357-2725(96)00032-5. PMID 8930118. 
  3. ^ "Entrez Gene: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3". 
  4. ^ Kroczynska B, Evangelista CM, Samant SS, Elguindi EC, Blond SY (March 2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352. 

Further reading[edit]

External links[edit]