Alpha 2-antiplasmin

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SERPINF2
2R9Y.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SERPINF2, A2AP, AAP, ALPHA-2-PI, API, PLI, serpin family F member 2
External IDs OMIM: 613168 MGI: 107173 HomoloGene: 719 GeneCards: 5345
RNA expression pattern
PBB GE SERPINF2 205075 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000934
NM_001165920
NM_001165921

NM_008878

RefSeq (protein)

NP_000925.2
NP_001159392.1
NP_001159393.1

NP_032904.1

Location (UCSC) Chr 17: 1.74 – 1.76 Mb Chr 11: 75.43 – 75.44 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.[1]

Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

Role in disease[edit]

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. This is associated with an increase risk of bleeding in liver disease.[2]

Interactions[edit]

Alpha 2-antiplasmin has been shown to interact with:

See also[edit]

References[edit]

  1. ^ "Entrez Gene: SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2". 
  2. ^ Sattar, Husain. Fundamentals of Pathology. Pathoma LLC, 2011, p. 36.
  3. ^ a b Shieh BH, Travis J (May 1987). "The reactive site of human alpha 2-antiplasmin". The Journal of Biological Chemistry 262 (13): 6055–9. PMID 2437112. 
  4. ^ Brower MS, Harpel PC (Aug 1982). "Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase". The Journal of Biological Chemistry 257 (16): 9849–54. PMID 6980881. 
  5. ^ Wiman B, Collen D (Sep 1979). "On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin". The Journal of Biological Chemistry 254 (18): 9291–7. PMID 158022. 

Further reading[edit]

External links[edit]