Alveolar septum

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Cryptococcosis of lung in patient with AIDS. Mucicarmine stain. Histopathology of lung shows widened alveolar septum containing a few inflammatory cells and numerous yeasts of Cryptococcus neoformans. The inner layer of the yeast capsule stain red .

The alveolar septum separates adjacent alveoli in lung tissue. The minimal components of an alveolar septum consist of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium. Thicker alveolar septa may also contain elastic fibers, type I collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and also monocytes.


  • Robbins and Cotran, Pathologic Basis of Disease, 7th Ed. pp 712–713.