Amine oxidase

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An amine oxidase is an enzyme that catalyzes the oxidative cleavage of alkylamines into aldehydes and ammonia:[1]

RCH2NH2 + H2O + O2 RCHO + NH3 + H2O2

Amine oxidases are divided into two subfamilies based on the cofactor they contain:

Class Cofactor Subclass Enzyme Commission number Human genes
Amine oxidase
(formerly EC
copper lysyl oxidase EC LOX
primary-amine oxidase EC AOC2, AOC3
diamine oxidase EC AOC1
Monoamine oxidase flavin N/A EC MAOA, MAOB


  1. ^ Mondovì B, Finazzi Agrò A (1982). "Structure and function of amine oxidase". Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Bioligy. 148: 141–53. doi:10.1007/978-1-4615-9281-5_12. ISBN 978-1-4615-9283-9. PMID 7124512.

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