Kopexil

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Kopexil
Kopexil tautomerism.svg
Names
IUPAC names
2,3-Dihydro-3-hydroxy-2-imino-4-pyrimidinamine
2,4-Diaminopyrimidine 3-N-oxide
Other names
Aminexil
Identifiers
3D model (JSmol)
ChemSpider
Properties
C4H6N4O
Molar mass 126.12 g·mol−1
Appearance white odorless crystals[1]
Melting point 210 to 218 °C (410 to 424 °F; 483 to 491 K)[1]
slightly soluble[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Kopexil (INCI name diaminopyrimidine oxide, trade name Aminexil) is a chemical compound similar to minoxidil. Minoxidil was originally used to treat high blood pressure; a side effect was increased body hair. Both compounds have been used for therapy of alopecia.[2] Kopexil is not approved for use as a drug in the United States or in Europe.

Chemical structure[edit]

Kopexil is an N-oxide, a group of substances in which the nitrogen atom of a tertiary amine is oxidized. The compound can exist in two tautomeric forms.

Mechanism of action[edit]

The exact mechanism of action of kopexil is unknown. There is no proof of therapeutic effect for kopexil against alopecia.[3]

References[edit]

  1. ^ a b c MSDS for Kopexil at Kumar Organics. March 28th 2012.
  2. ^ Trüeb RM, de Viragh PA: Status of scalp hair and therapy of alopecia in men in Switzerland; PMID 11256223.
  3. ^ Wolfgang Raab: Haarerkrankungen in der dermatologischen Praxis, p. 82, at Google Books (German).