Aminocarboxymuconate-semialdehyde decarboxylase
| aminocarboxymuconate-semialdehyde decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 aminocarboxymuconate-semialdehyde decarboxylase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 4.1.1.45 | ||||||||
| CAS no. | 37289-47-7 | ||||||||
| Alt. names | ACMSD | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) catalyzes the chemical reaction:[1]
The product spontaneously ring-closes to picolinic acid, with loss of water.[2][3]
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. This enzyme is part of the kynurenine pathway in tryptophan metabolism, leading to picolinic acid or quinolinic acid.[3] It has been identified as a marker in nonverbal autism.[4]
Nomenclature
[edit]The systematic name of this enzyme class is 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming). Other names in common use include picolinic acid carboxylase, picolinic acid decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde, beta-decarboxylase, 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase, and 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase.[1]
References
[edit]- 1 2 Enzyme 4.1.1.45 at KEGG Pathway Database.
- ↑ Ichiyama A, Nakamura S, Kawai H, Honjo T, Nishizuka Y, Hayaishi O, et al. (1965). "Studies on the Metabolism of the Benzene Ring of Tryptophan in Mammalian Tissues". Journal of Biological Chemistry. 240 (2): 740–749. doi:10.1016/S0021-9258(17)45238-0.
- 1 2 Savitz J (January 2020). "The kynurenine pathway: a finger in every pie". Molecular Psychiatry. 25 (1): 131–147. doi:10.1038/s41380-019-0414-4. PMC 6790159. PMID 30980044.
- ↑ Kainer D, Templeton AR, Prates ET, Jacboson D, Allan ER, Climer S, et al. (January 2023). "Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder". HGG Advances. 4 (1) 100150. doi:10.1016/j.xhgg.2022.100150. PMC 9634371. PMID 36340933.
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