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Pancuronium, the first aminosteroid neuromuscular blocking agent to be introduced.

Aminosteroids are a group of steroids with a similar structure based on an amino-substituted steroid nucleus.[1][2] They are neuromuscular blocking agents, acting as competitive antagonists of the nicotinic acetylcholine receptor (nAChR), and block the signaling of acetylcholine in the nervous system.[1][2][3] These drugs include candocuronium iodide (chandonium iodide), dacuronium bromide, dihydrochandonium, dipyrandium, malouetine, pancuronium bromide, pipecuronium bromide, rapacuronium bromide, rocuronium bromide, stercuronium iodide, and vecuronium bromide.[2][4]

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  1. ^ a b Ted Lin; Tim Smith; Colin Pinnock (1 December 2016). Fundamentals of Anaesthesia. Cambridge University Press. pp. 650–. ISBN 978-1-316-66678-4.
  2. ^ a b c Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 336–337. ISBN 978-1-60913-345-0.
  3. ^ Alexandra Dugdale (28 November 2011). Veterinary Anaesthesia: Principles to Practice. John Wiley & Sons. pp. 144–. ISBN 978-1-118-27933-5.
  4. ^ "Reference at" (PDF).