A doctor by training, Safana was a graduate of Ahmadu Bello University and the Universities of Leeds and London. He had been a confidant of President Umaru Yar'Adua, and had served as secretary of Katsina State's government while Yar'Adua was governor.
He was elected to the House of Representatives in 2003, and was reelected in 2007. He was a People's Democratic Party member and chairman of the house's Committee on Health. On October 17, 2007, Safana collapsed on the assembly's floor; he was pronounced dead the same day at the Abuja National Hospital, the cause of death being identified as a heart attack.
- Ohuegbe, Chuks (2007-10-20). "Lingering House Crisis Killed My Husband -- Safana's Widow". Leadership. Leadership Newspapers Group. Archived from the original on 2007-12-14. Retrieved 2007-10-21.
- "Hon. Aminu Shuaibu Safana". NassNig.org. National Assembly of Nigeria. Archived from the original on 2007-10-20. Retrieved 2007-10-21.
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