3D model (Jmol)
|Molar mass||260.28 g/mol|
|Melting point||decomp ~ 155 °C|
|Hill, B; Lerner, H-W; Bolte, M (2010). "Redetermination of diammonium thiomolybdate". Acta Crystallographica E. 66 (13): i13. doi:10.1107/S1600536810003016.|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Ammonium tetrathiomolybdate is the chemical compound with the formula (NH4)2MoS4. This bright red ammonium salt is an important reagent in the chemistry of molybdenum and has been used as a building block in bioinorganic chemistry. The thiometallate anion has the distinctive property of undergoing oxidation at the sulfur centers concomitant with reduction of the metal from Mo(VI) to Mo(IV).
Preparation and structure
- (NH4)2MoO4 + 4 H2S → (NH4)2MoS4 + 4 H2O
The anion is also an excellent ligand. For example, with Ni(II) sources, it forms [Ni(MoS4)2]2−. Much of the chemistry of the thiomolybdate results from studies on salts of quaternised organic cations, such as [NEt4]2[MoS4] and [PPh4]2[MoS4] (Et = C2H5, Ph = C6H5). These organic salts are soluble in polar organic solvents such as acetonitrile and dmf.
- (NH4)2MoS4 → MoS3 + 2 NH3 + H2S
MoS3 then decomposes again to molybdenum disulfide (MoS2) in a broad temperature range from 300 °C to 820 °C. Perfect decomposition to MoS2 under inert gas requires at least 800 °C according to the following reaction,
- MoS3 → MoS2 + S
but it can also be achieved at 450 °C, if there is enough hydrogen.
- MoS3 + H2 → MoS2 + H2S
Several related thio and seleno anions are known including (A = alkali metal cation, [PPh4]+, [NEt4]+)
- MoS42− (Bis-choline tetrathiomolybdate)
More complex tetrahedral anions include A2[MoS4−xOx] and A2[WS4−xOx]
Ammonium tetrathiomolybdate was first used therapeutically in the treatment of copper toxicosis in animals. It was then introduced as a treatment in Wilson's disease, a hereditary copper metabolism disorder, in humans; it acts both by competing with copper absorption in the bowel and by increasing excretion. Clinical studies have shown ATTM can effectively lower copper levels faster than currently available treatments, and that fewer patients with an initial neurological presentation of their disease who are treated with ATTM experience neurological deterioration 
ATTM has also been found to have an inhibitory effect on angiogenesis, potentially via the inhibition of Cu ion dependent membrane translocation process involving a non-classical secretion pathway. This makes it an interesting investigatory treatment for cancer, age-related macular degeneration, and other diseases featuring excessive blood vessel deposition.
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- Coucouvanis, D (1998). "Syntheses, structures, and reactions of binary and tertiary thiomolydate complexes containing the (O)Mo(Sx) and (S)Mo(Sx) functional groups (x = 1, 2, 4)". Advances in Inorganic Chemistry. 45: 1–73. doi:10.1016/S0898-8838(08)60024-0. ISBN 978-0-12-023645-9.
- Brito, JL; Ilija, M; Hernández, P (1995). "Thermal and reductive decomposition of ammonium thiomolybdates". Thermochimica Acta. 256 (2): 325. doi:10.1016/0040-6031(94)02178-Q.
- Lee, SC; Li, J; Mitchell, JC; Holm, RH (1992). "Group 5 tetrathiometalates: Simplified syntheses and structures". Inorg. Chem. 31 (21): 4333–4338. doi:10.1021/ic00047a021.
- Srinivasan, BR; Poisot, M; Näther, C; Bensch, W (2004). "Diammonium tetrathiotungstate(VI), [NH4]2[WS4], at 150 K". Acta Crystallographica E. E60 (11): i136–8. doi:10.1107/S1600536804023761.
- Goodman, JT; Rauchfuss, TB (2002). "Tetraethylammonium-tetrathioperrhenate [Et4N][ReS4]". Inorganic Syntheses. 33: 107–110. doi:10.1002/0471224502.ch2. ISBN 0471208256.
- Compound Summary for Bis-choline tetrathiomolybdate
- Brewer, GJ; Hedera, P; Kluin, KJ; Carlson, M; et al. (2003). "Treatment of Wilson disease with ammonium tetrathiomolybdate: III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy". Arch Neurol. 60 (3): 379–85. doi:10.1001/archneur.60.3.379. PMID 12633149.
- Brewer, GJ; Askari, F; Lorincz, MT; Carlson, M; et al. (2006). "Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease". Arch Neurol. 63 (4): 521–7. doi:10.1001/archneur.63.4.521. PMID 16606763.
- Brewer, GJ; Askari, F; Dick, RB; Sitterly, J; et al. (2009). "Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine". Translational Research. 154 (2): 70–7. doi:10.1016/j.trsl.2009.05.002. PMID 19595438.
- Nickel, W (2003). "The Mystery of nonclassical protein secretion, a current view on cargo proteins and potential export routes". Eur. J. Biochem. 270 (10): 2109–2119. doi:10.1046/j.1432-1033.2003.03577.x. PMID 12752430.