Amniotic fluid embolism

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Amniotic fluid embolism
Amniotic fluid embolism.jpg
Classification and external resources
Specialty obstetrics
ICD-10 O88.1
ICD-9-CM 673.1
DiseasesDB 574
eMedicine med/122
MeSH D004619
Pathophysiology of the amniotic fluid embolism

An amniotic fluid embolism (AFE) is a rare childbirth (obstetric) emergency in which amniotic fluid, enters the blood stream of the mother to trigger a serious reaction. This reaction then results in cardiorespiratory (heart and lung) collapse and massive bleeding (coagulopathy).[1][2][3]

Signs and symptoms[edit]

Amniotic fluid embolism is suspected when a woman giving birth experiences very sudden insufficient oxygen to body tissues, low blood pressure, and profuse bleeding due to defects in blood coagulation. Though symptoms and signs can be profound, they also can be entirely absent. There is much variation in how each instance progresses.[2]


AFE is very rare and complex. The disorder occurs during the last stages of labor when amniotic fluid enters the circulatory system of the mother. Upon later analysis, fetal cells are found in the maternal circulation. When the fetal cells and amniotic fluid enters the bloodstream, reactions occur that causes severe changes in the mechanisms that affect blood clotting. Intravascular coagulation occurs and results in serious bleeding. The condition can also develop after elective abortion, amniocentesis, cesarean delivery or trauma. Small lacerations in the lower reproductive tract are associated with AFE.[2]

The use of drugs to induce labor, such as misoprostol, nearly doubles the risk of AFE. A maternal age of 35 years or older is associated with AFE.[4]


AFE is diagnosed when all other causes have been excluded. The presence of fetal squamous cells or other fetal tissues, including meconium have been found in the maternal circulation after the event. Diagnosis is also based upon the signs and symptoms observed during the birth or procedures.[2]


Treatment is supportive.Since the circumstances that lead to this complication can not be controlled, treatment to resolve the symptoms and deteriorating vascular conditions can improve outcomes.[2]


Amniotic fluid embolism is very uncommon and the rate at which it occurs is 1 instance per 20,000 births. Though rare, it comprises 10% of all maternal deaths.[2]


This rare complication has been recorded seventeen times prior to 1950. It was first described in Brazil in the 1920s.[5]


  1. ^ Stafford, Irene; Sheffield, Jeanne (2007). "Amniotic Fluid Embolism". Obstetrics and Gynecology Clinics of North America. 34 (3): 545–553. ISSN 0889-8545. doi:10.1016/j.ogc.2007.08.002. [subscription required]
  2. ^ a b c d e f Stein, Paul (2016). Pulmonary embolism. Chichester, West Sussex, UK Hoboken, NJ: John Wiley & Sons Inc. ISBN 9781119039099. 
  3. ^ *Leveno, Kenneth (2016). Williams manual of pregnancy complications. New York: McGraw-Hill Medical. pp. 223–224. ISBN 9780071765626. 
  4. ^ Kramer, M.S.; Rouleau, Jocelyn; Baskett, Thomas F; Joseph, KS (2006). "Amniotic-fluid embolism and medical induction of labour: a retrospective, population-based cohort study". The Lancet. 368 (9545): 1444–1448. PMID 17055946. doi:10.1016/S0140-6736(06)69607-4. 
  5. ^ Amniotic fluid embolus: An update. Alfredo Gei, Gary D. V. Hankins: Contemp Ob/Gyn 45 (2000)

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