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Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
CAS Number 78613-35-1 YesY
ATC code D01AE16 (WHO)
PubChem CID 54260
ChemSpider 49010 YesY
KEGG D02923 YesY
ChEBI CHEBI:599440 YesY
Chemical data
Formula C21H35NO
Molar mass 317.509 g/mol

Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits Δ14-sterol reductase and cholestenol Δ-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.[1]

It is a topical solution for the treatment of toenail infections. Systemic treatments may be considered more effective.[1]

It is approved for sale over-the-counter in Australia, Russia and the UK (recently re-classified to over-the-counter status), and is approved for the treatment of toenail fungus by prescription in other countries. It is not approved for the treatment of onychomycosis in the United States or Canada, but can be ordered from there by mail from other countries.[2]


  1. ^ a b Hywel C. Williams (2003). Evidence-Based Dermatology. Blackwell. 
  2. ^ It can readily be verified that Curanail is advertised on websites such as US, shipped from abroad.