Amphigeneia (Ancient Greek: Ἀμφιγένεια) was a city in ancient Greece. It was located in either Messenia or in Triphylia. According to Strabo it was situated at the river Hypsoeis, and there was a sanctuary of Leto in the city. According to Homer, it belonged to Nestor of Pylos. Pausanias visited the area but does not mention the city, which might indicate that it had been abandoned before the 2nd century AD. The ancient Eleans believed that Apollo was born here. The location of the ancient city is unknown.