Ampicillin is a moderate-spectrum penicillin antibiotic with good cover against group A streptococcal infection, whilst flucloxacillin is a narrow-spectrum antibiotic with cover against Staphylococcus aureus. The combination covers the two most likely bacteria in cellulitis infections in the arm or leg.
Side effects and contraindications
Side effects are the same as per the individual components, with stomach or bowel upset from the flucloxacillin being the most common. Both parts are members of the penicillin family of antibiotics, so should not be taken by patients allergic to penicillin. See flucloxacillin for additional contraindications.