Amylmetacresol

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Amylmetacresol
Amylmetacresol.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
ECHA InfoCard100.013.722 Edit this at Wikidata
Chemical and physical data
FormulaC12H18O
Molar mass178.27
3D model (JSmol)
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Amylmetacresol (AMC) is an antiseptic used to treat infections of the mouth and throat. It is used as an active pharmaceutical ingredient in Strepsils, Cēpacol, Gorpils and Lorsept throat lozenges.

Chemically, AMC is derivative of m-cresol, with a pentyl group attached to the sixth carbon atom. The pure substance melts at 24 °C, and boils between 137 to 139 °C (at 6.7 kPa). It is soluble in water, ethanol, acetone, ether, and oil. AMC exhibits low toxicity, and a RW coefficient of 250.[1]

See also[edit]

References[edit]

  1. ^ Twort, CC; Baker, AH (1942). "Further Researches on Bactericidal Mists and Smokes". The Journal of Hygiene. 42 (3): 266–283. doi:10.1017/s0022172400035476. PMC 2199819. PMID 20475630.

External links[edit]

  • C. E. Coulthard (1931). "The Disinfectant and Antiseptic Properties of Amyl-meta-cresol". J Exp Patho. 12 (5): 331–336. PMC 2048245.
  • Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A (2005). "A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV". Antivir Chem Chemother. 16 (2): 129–34. doi:10.1177/095632020501600205. PMID 15889535.
  • McNally D, Shephard A, Field E (2012). "Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection". J Pharm Pharm Sci. 15 (2): 281–94. doi:10.18433/j31309. PMID 22579007.
  • Weckmann G, Hauptmann-Voß A, Baumeister SE, Klötzer C, Chenot JF (2017). "Efficacy of AMC/DCBA lozenges for sore throat: A systematic review and meta-analysis". Int J Clin Pract. 71 (10): 1742–1241. doi:10.1111/ijcp.13002. PMID 28869700.