After attending Iona Catholic Secondary School in Mississauga, Ontario, Andre Durie played CIS football for York University in Toronto. He started playing for the York Lions in 2003 after he set a junior Ontario Varsity Football League record with 22 touchdowns in a season. In 2004, Durie had a record-breaking season starting eight games at running back and set an Ontario University Athletics record for single game rushing yards with 349 and single-season York records for rushing yards (1,367), scoring (96 points), and rushing touchdowns (15), and a career York record for rushing touchdowns (23). Durie also tied a CIS single-game record with six touchdowns to lead York to a 55-33 win over Waterloo.
In the second game of the 2005 season he suffered nerve damage in his knee after a botched juke on third down and sat out the remainder of 2005 and 2006 seasons.
After overcoming injuries that hurt his CIS career, Durie impressed the Argonauts management at the league evaluation camp and he appeared in 5 games for the Argos in 2007. After suffering another injury setback which has cost Durie more than half of the 2008 season he returned to action on special teams and as back-up running back.
In 2009, Durie dressed for all 18 games including weeks 1-5 as backup running back. In week 6 he made the switch to slotback and has remained in that role since, although still a backup. In this same season, he attatined a 1000 yard kickoff return season, becoming the fourth Argonaut to do so, with 43 returns for 1033 yards. In the 2010 season, Durie won a job in the starting lineup as a RB/SB, but sees most of his touches as a receiver.
In 2012, Durie won his first Grey Cup, defeating the Calgary Stampeders, scoring a touchdown in the 35-22 win. Durie had his best receiving season of his career during the 2013 CFL seaosn, setting career highs in receptions with 92 and yards with 986. Following the 2013 season Durie re-signed with the Argos through the 2016 CFL season, a deal that will reportedly earn around $140,000 annually.