Andrew N. J. McKenzie

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Andrew McKenzie
FRS FMedSci
Andrew N. J. McKenzie Royal Society.jpg
Andrew McKenzie at the Royal Society admissions day in London, July 2017
Born Andrew Neil James McKenzie
Education University of London (PhD)
Scientific career
Fields Immunology
Autoimmunity
Molecular biology
Institutions Laboratory of Molecular Biology
University of Cambridge
National Institute for Medical Research[1]
Thesis Cellular and humoral aspects of the immune response of the larval stages of Calliphora vomitoria L. (Insecta: Diptera) (1988)
Website www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/andrew-mckenzie/

Andrew Neil James McKenzie FRS FMedSci[2] is a molecular biologist and group leader in the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB).[3]

Education[edit]

McKenzie was educated at the University of London where he was awarded a PhD for research on the immune response of the bluebottle fly (Calliphora vomitoria),[4] covering both humoral immunity and cell-mediated immunity.

Research and career[edit]

McKenzie's research investigates how the innate immune system and adaptive immune system protect the body from infection, but can also lead to inflammation and pathology.[2] He has defined and characterised how biological networks orchestrate responses to pathogens and how dysregulation of these biological pathways can lead to diseases such as asthma and allergy.[2][5]

His identification of the cytokine Interleukin 13 and the subsequent unearthing of its central role in allergic asthma led to his discovery of type-2 innate lymphoid cells (ILC2).[6][7] These cells secrete large quantities of cytokines and represent a new druggable biological target for intervention in inflammation and infection.[2]

Awards and honours[edit]

McKenzie was elected a Fellow of the Royal Society (FRS) in 2017[2] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2011.[citation needed]

References[edit]

  1. ^ McKenzie, Andrew N.J.; Ely, Barry; Sanderson, Colin J. (1991). "Mutated interleukin-5 monomers are biologically inactive". Molecular Immunology. 28 (1-2): 155–158. doi:10.1016/0161-5890(91)90099-6. ISSN 0161-5890. PMID 1901378. 
  2. ^ a b c d e Anon (2017). "Dr Andrew McKenzie FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 2017-05-05.  One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)

  3. ^ Andrew N. J. McKenzie publications indexed by the Scopus bibliographic database. (subscription required)
  4. ^ McKenzie, Andrew Neil James (1988). Cellular and humoral aspects of the immune response of the larval stages of Calliphora vomitoria L. (Insecta: Diptera). london.ac.uk (PhD thesis). University of London. OCLC 940318709. 
  5. ^ Neill, Daniel R.; Wong, See Heng; Bellosi, Agustin; Flynn, Robin J.; Daly, Maria; Langford, Theresa K. A.; Bucks, Christine; Kane, Colleen M.; Fallon, Padraic G.; Pannell, Richard; Jolin, Helen E.; McKenzie, Andrew N. J. (2010). "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity". Nature. 464 (7293): 1367–1370. doi:10.1038/nature08900. ISSN 0028-0836. PMC 2862165Freely accessible. PMID 20200518. 
  6. ^ Spits, Hergen; Artis, David; Colonna, Marco; Diefenbach, Andreas; Di Santo, James P.; Eberl, Gerard; Koyasu, Shigeo; Locksley, Richard M.; McKenzie, Andrew N. J.; Mebius, Reina E.; Powrie, Fiona; Vivier, Eric (2013). "Innate lymphoid cells — a proposal for uniform nomenclature". Nature Reviews Immunology. 13 (2): 145–149. doi:10.1038/nri3365. ISSN 1474-1733. PMID 23348417.  (subscription required)
  7. ^ Newland, Stephen A.; Mohanta, Sarajo; Clément, Marc; Taleb, Soraya; Walker, Jennifer A.; Nus, Meritxell; Sage, Andrew P.; Yin, Changjun; Hu, Desheng; Kitt, Lauren L.; Finigan, Alison J.; Rodewald, Hans-Reimer; Binder, Christoph J.; McKenzie, Andrew N. J.; Habenicht, Andreas J.; Mallat, Ziad (2017). "Type-2 innate lymphoid cells control the development of atherosclerosis in mice". Nature Communications. 8: 15781. doi:10.1038/ncomms15781. ISSN 2041-1723. PMC 5467269Freely accessible. PMID 28589929.  open access publication – free to read