Androgen-dependent condition

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An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body.

Known androgen-dependent conditions include acne,[1] seborrhea,[2][3][4] androgenic alopecia,[5] hirsutism,[6] hidradenitis suppurativa,[7] precocious puberty in boys,[8] hypersexuality,[9] paraphilias,[10] benign prostatic hyperplasia (BPH),[11] prostate cancer,[12] and hyperandrogenism in women such as in polycystic ovary syndrome (PCOS).[13][14]

Such conditions may be treated with drugs with antiandrogen actions, including androgen receptor antagonists such as cyproterone acetate, spironolactone, and bicalutamide, 5α-reductase inhibitors such as finasteride and dutasteride, CYP17A1 inhibitors such as abiraterone acetate, gonadotropin-releasing hormone (GnRH) analogues such as leuprolide and cetrorelix, and/or other antigonadotropins such as megestrol acetate and medroxyprogesterone acetate.[15][16]

See also[edit]

References[edit]

  1. ^ Joseph E. Pizzorno; Michael T. Murray (2013). Textbook of Natural Medicine. Elsevier Health Sciences. pp. 1157–. ISBN 1-4377-2333-0. 
  2. ^ Steven B. Hoath; Howard I. Maibach (18 April 2003). Neonatal Skin: Structure and Function. CRC Press. pp. 67–. ISBN 978-0-8247-0887-0. 
  3. ^ Mariagrazia Stracquadanio; Lilliana Ciotta (20 April 2015). Metabolic Aspects of PCOS: Treatment With Insulin Sensitizers. Springer International Publishing. pp. 25–. ISBN 978-3-319-16760-2. 
  4. ^ Krishna; Usha R. (1 March 2000). Adolescence. Orient Blackswan. pp. 124–. ISBN 978-81-250-1794-3. 
  5. ^ Mark G. Lebwohl; Warren R. Heymann; John Berth-Jones; Ian Coulson (19 September 2013). Treatment of Skin Disease: Comprehensive Therapeutic Strategies. Elsevier Health Sciences UK. pp. 36–. ISBN 978-0-7020-5236-1. 
  6. ^ Wilma F. Bergfeld (22 February 1996). A Woman Doctor's Guide to Skin Care: Essential Facts and Information on Keeping Skin Healthy. Hyperion. ISBN 978-0-7868-8100-0. 
  7. ^ Sarah Bekaert (2007). Women's Health: A Practical Guide for Healthcare Professionals. Radcliffe Publishing. pp. 128–. ISBN 978-1-84619-029-2. 
  8. ^ Ora Hirsch Pescovitz; Erica A. Eugster (2004). Pediatric Endocrinology: Mechanisms, Manifestations, and Management. Lippincott Williams & Wilkins. pp. 328–. ISBN 978-0-7817-4059-3. 
  9. ^ Newsletter. The Academy. 1986. 
  10. ^ Adrian Raine (2006). Crime and Schizophrenia: Causes and Cures. Nova Publishers. pp. 290–. ISBN 978-1-59454-609-9. 
  11. ^ Christopher R. Chapple; William D. Steers (10 May 2011). Practical Urology: Essential Principles and Practice: Essential Principles and Practice. Springer Science & Business Media. pp. 361–. ISBN 978-1-84882-034-0. 
  12. ^ P. J. Bentley (1980). Endocrine Pharmacology: Physiological Basis and Therapeutic Applications. CUP Archive. pp. 321–. ISBN 978-0-521-22673-8. 
  13. ^ Raphael Rubin; David S. Strayer; Emanuel Rubin; Jay M. McDonald (2008). Rubin's Pathology: Clinicopathologic Foundations of Medicine. Lippincott Williams & Wilkins. pp. 816–. ISBN 978-0-7817-9516-6. 
  14. ^ Andrea Dunaif; R. Jeffrey Chang; Stephen Franks; Richard S. Legro (12 January 2008). Polycystic Ovary Syndrome: Current Controversies, from the Ovary to the Pancreas. Springer Science & Business Media. pp. 222–. ISBN 978-1-59745-108-6. 
  15. ^ Kenneth L. Becker (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 1195–. ISBN 978-0-7817-1750-2. 
  16. ^ Annual Reports in Medicinal Chemistry. Academic Press. 3 October 1994. pp. 1994–. ISBN 978-0-08-058373-0. 

Further reading[edit]

  • Shukla, G. C.; Plaga, A. R.; Shankar, E.; Gupta, S. (2016). "Androgen receptor-related diseases: what do we know?". Andrology: n/a–n/a. doi:10.1111/andr.12167. ISSN 2047-2919.