Mosso began by recording the pulsation of the human cortex in patients with skull defects following neurosurgical procedures. From his findings that these pulsations change during mental activity, he inferred that during mental activities blood flow increases to the brain. Remarkably, Mosso invented the 'human circulation balance', only recently rediscovered, to non-invasively measure the redistribution of blood during emotional and intellectual activity also in healthy subjects: this is therefore regarded as the first neuroimaging technique ever, forerunner of the more refined techniques of FMRI, and PET.
He was born in Turin, studied medicine there and in Florence, Leipzig, and Paris, and was appointed professor of pharmacology (1876) and professor of physiology (1879) at Turin. He invented various instruments to measure the pulse and experimented and wrote upon the variation in the volume of the pulse during sleep, mental activity, or emotion. In 1900–01 he visited the United States and embodied the results of his observations in Democrazia nella religione e nella scienza: studi sull' America (1901). In 1882 he founded with Emery the Archives Italiennes de Biologie, in which journal most of his essays appeared. Among his other works are:
- Die Diagnostik des Pulses (1879)
- Sulla paura (1884)
- La paura (1891; English translation by E. Lough and F. Kiesow, Fear, London, 1896)
- La fatica (1891; English translation by M. A. and W. B. Drummond, Fatigue, New York, 1904)
- La Temperatura del cervello (1894)
- Fisiologia dell' uomo sulle Alpi (1897; third edition, 1909)
- Mens Sana in Corpore Sano (1903)
- Vita moderna degli Italiani (1905)
- Escursioni nel mediterraneo e gli scavi di Creta (1907; second edition, 1910; English translation, The Palaces of Crete and their Builders, New York, 1908)
- La preistoria: original della civilta mediterranea (1910; English translation by M. C. Harrison, The Dawn of Mediterranean Civilization, New York, 1911)
- Nuovo Antologia (in collaboration)
Mosso was elected a member of the Royal Swedish Academy of Sciences in 1897.
- Mosso's balance, rediscovered by Stefano Sandrone and colleagues
- Mosso's ergograph — (1890) An apparatus for recording the force and frequency of flexion of the fingers
- Mosso's sphygmomanometer — An instrument for measuring blood pressure in the arteries
- Sandrone, Stefano (2014). "Weighing brain activity with the balance: Angelo Mosso's original manuscripts come to light". Brain. 137: 621–633. doi:10.1093/brain/awt091. PMID 23687118.
- Sandrone, Stefano; Bacigaluppi, Marco; Galloni, Marco R.; Martino, Gianvito (2012). "Angelo Mosso (1846–1910)". Journal of Neurology. 259: 2513–2514. doi:10.1007/s00415-012-6632-1. PMID 23010944.
- New International Encyclopedia (edition, date?)
- Ergograph according to Mosso, modified by Lombard. Max Planck Institute for the History of Science, Berlin
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- Works by Angelo Mosso at Project Gutenberg
- Works by or about Angelo Mosso at Internet Archive
- Biography in English
- Mosso's first neuroimaging experiment ever
- Biography in Italian
- Short biography and bibliography in the Virtual Laboratory of the Max Planck Institute for the History of Science
- Some places and memories related to Angelo Mosso on Himetop – The History of Medicine Topographical Database