Angelo Mosso

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Angelo Mosso in the 1880s

Angelo Mosso (30 May 1846 – 24 November 1910) is the 19th century Italian physiologist who invented the first neuroimaging technique ever, known as 'human circulation balance'.[1]

Mosso began by recording the pulsation of the human cortex in patients with skull defects following neurosurgical procedures. From his findings that these pulsations change during mental activity, he inferred that during mental activities blood flow increases to the brain. Remarkably, Mosso invented the 'human circulation balance', only recently rediscovered, to non-invasively measure the redistribution of blood during emotional and intellectual activity also in healthy subjects: this is therefore regarded as the first neuroimaging technique ever, forerunner of the more refined techniques of FMRI, and PET.[1]

He was born in Turin, studied medicine there and in Florence, Leipzig, and Paris, and was appointed professor of pharmacology (1876) and professor of physiology (1879) at Turin.[2] He invented various instruments to measure the pulse and experimented and wrote upon the variation in the volume of the pulse during sleep, mental activity, or emotion. In 1900–01 he visited the United States and embodied the results of his observations in Democrazia nella religione e nella scienza: studi sull' America (1901).[3] In 1882 he founded with Emery the Archives Italiennes de Biologie, in which journal most of his essays appeared. Among his other works are:

Mosso was elected a member of the Royal Swedish Academy of Sciences in 1897.


  • Mosso's balance, rediscovered by Stefano Sandrone and colleagues[1]
  • Mosso's ergograph — (1890) An apparatus for recording the force and frequency of flexion of the fingers[7]
  • Mosso's sphygmomanometer — An instrument for measuring blood pressure in the arteries
The American Illustrated Medical Dictionary (1938)


  1. ^ a b c Sandrone, Stefano (2014). "Weighing brain activity with the balance: Angelo Mosso's original manuscripts come to light". Brain. 137 (Pt 2): 621–633. doi:10.1093/brain/awt091. PMID 23687118.
  2. ^ Sandrone, Stefano; Bacigaluppi, Marco; Galloni, Marco R.; Martino, Gianvito (2012). "Angelo Mosso (1846–1910)". Journal of Neurology. 259 (11): 2513–2514. doi:10.1007/s00415-012-6632-1. PMID 23010944.
  3. ^ New International Encyclopedia[citation needed] (edition, date?)
  4. ^ Life of man on the high Alps by Angelo Mosso, trans. from the 2nd edition by E. Lough Kiesow. 1898.
  5. ^ Mosso, Angelo (1907). The Palaces of Crete and their Builders.
  6. ^ "Review of The Palaces of Crete and their Builders by Angelo Mosso". The Athenæum (4183): 833–834. 28 December 1907.
  7. ^ Ergograph according to Mosso, modified by Lombard. Max Planck Institute for the History of Science, Berlin

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