Angiomotin-like protein 1

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AMOTL1
Identifiers
AliasesAMOTL1, JEAP, angiomotin like 1
External IDsMGI: 1922973 HomoloGene: 43977 GeneCards: AMOTL1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for AMOTL1
Genomic location for AMOTL1
Band11q21Start94,706,431 bp[1]
End94,876,748 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301007
NM_130847

NM_001081395

RefSeq (protein)

NP_001287936
NP_570899
NP_570899.1

NP_001074864

Location (UCSC)Chr 11: 94.71 – 94.88 MbChr 9: 14.54 – 14.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.[5][6]

Function[edit]

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166025 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013076 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y (Feb 2002). "JEAP, a novel component of tight junctions in exocrine cells". J Biol Chem. 277 (7): 5583–7. doi:10.1074/jbc.M110154200. PMID 11733531.
  6. ^ a b "Entrez Gene: AMOTL1 angiomotin like 1".

External links[edit]

Further reading[edit]