Angiopoietin-related protein 2

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Aliases ANGPTL2, ARP2, HARP, angiopoietin like 2
External IDs MGI: 1347002 HomoloGene: 22695 GeneCards: ANGPTL2
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for ANGPTL2
Genomic location for ANGPTL2
Band 9q33.3 Start 127,087,332 bp[1]
End 127,122,883 bp[1]
RNA expression pattern
PBB GE ANGPTL2 219514 at fs.png

PBB GE ANGPTL2 213001 at fs.png

PBB GE ANGPTL2 213004 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 127.09 – 127.12 Mb Chr 9: 33.22 – 33.25 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene.[5][6]


Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of metabolic diseases. ANGPTL2 has a role also in angiogenesis, in tissue repair, in obesity, in atherosclerotic diseases and finally in cancerogenesis. [7]

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136859 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004105 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kim I, Moon SO, Koh KN, Kim H, Uhm CS, Kwak HJ, Kim NG, Koh GY (Oct 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol Chem. 274 (37): 26523–8. doi:10.1074/jbc.274.37.26523. PMID 10473614. 
  6. ^ a b "Entrez Gene: ANGPTL2 angiopoietin-like 2". 
  7. ^!/content/playContent/1-s2.0-S1043276014000599?

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