From Wikipedia, the free encyclopedia
Jump to: navigation, search
Epithelioid angiosarcoma - high mag.jpg
Micrograph of an angiosarcoma. H&E stain.
Classification and external resources
ICD-10 C49.9
ICD-O M9120/3
eMedicine med/138
MeSH D006394
Orphanet 263413

Angiosarcoma is a cancer of the cells that line the walls of blood vessels or lymphatic vessels. The lining of the vessel walls is called the endothelium. Cancers from the walls of blood vessels are called hemangiosarcomas, and cancers from the walls of lymphatic vessels are called lymphangiosarcomas.

Most tumors of visceral blood and lymphatic vessel walls are cancerous (malignant). Because these cancers are carried by the blood flow or lymphatic flow, they can more easily metastasize to distant sites, particularly the liver and lungs.

Angiosarcomas will show signs of hemorrhage and necrosis. Pathologically, tumor cells will show increased nuclear to cytoplasm ratio, nuclear hyperchromasia, nuclear pleomorphism and high mitotic activity.[1]

In dogs, hemangiosarcoma is relatively common, especially in larger breeds such as golden retrievers and Labrador retrievers.[citation needed] In humans, hemangiosarcomas and lymphangiosarcomas of the skin are uncommon.[citation needed] Angiosarcoma of the liver, a rare fatal tumor, has been seen in workers intensively exposed to the gas vinyl chloride monomer (VCM) for prolonged periods while working in polyvinyl chloride (PVC) polymerization plants. It has also been associated with individuals exposed to arsenic-containing insecticides and Thorotrast.[citation needed]

See also[edit]


  1. ^ Perkins, [edited by] Vinay Kumar, Abul K. Abbas, Jon C. Aster ; artist, James A. (2013). Robbins basic pathology (9th ed.). Philadelphia, PA: Elsevier/Saunders. ISBN 9781437717815. 

External links[edit]