This article needs additional citations for verification. (June 2010) (Learn how and when to remove this template message)
A substance is anhydrous if it contains no water. Many processes in chemistry can be impeded by the presence of water, therefore, it is important that water-free reagents and techniques are used. In practice, however, it is very difficult to achieve perfect dryness; anhydrous compounds gradually absorb water from the atmosphere so they must be stored carefully.
Many salts and solids can be dried using heat, or under vacuum. Dessicators can also be used to store reagents in dry conditions.
Common dessicants include phosphorus pentoxide or silica gel.
Chemists may also require dry glassware for sensitive reactions. This can be achieved by drying glassware in an oven, by flame, or under vacuum.
Dry solids can be produced by freeze-drying/lyophilisation.
Liquids or solvents
In many cases, the presence of water can prevent a reaction from happening, or cause undesirable products to form. To prevent this, anhydrous solvents must be used when performing certain reactions. Examples of reactions requiring the use of anhydrous solvents are the Grignard reaction and the Wurtz reaction.
Solvents have typically been dried using distillation or by reaction with reactive metals or metal hydrides. These methods can be dangerous and are a common cause of lab fires. More modern techniques include the use of molecular seives or a column purification system. Molecular seives are far more effective than most common methods for drying solvents and are safer and require no special equipment for handling. Column solvent purification devices (generally referred to as Grubb's columns) recently became available, reducing the hazards (water reactive substances, heat) from the classical dehydrating methods. 
Anhydrous solvents are commercially available from chemical suppliers, and are packaged in sealed containers to maintain dryness. Typically anhydrous solvents will contain approximately 10 ppm of water and will increase in wetness if they are not properly stored.
Organic solutions can be dried using a range of drying agents. Typically following a workup the organic extract is dried using magnesium sulphate or a similar drying agent to remove most remaining water.
Several substances that exist as gases at standard conditions of temperature and pressure are commonly used as concentrated aqueous solutions. To clarify that it is the gaseous form that is being referred to, the term anhydrous is prefixed to the name of the substance:
- gaseous ammonia is generally referred to as anhydrous ammonia to distinguish it from household ammonia, which is an ammonium hydroxide aqueous solution
- gaseous hydrogen chloride is generally referred to as anhydrous to distinguish it from the more commonly used 37% w/w solution in water
Reactions which produce water can be kept dry using a Dean-Stark apparatus.
- Williams, D. Bradley G.; Lawton, Michelle (2010-12-17). "Drying of Organic Solvents: Quantitative Evaluation of the Efficiency of Several Desiccants". The Journal of Organic Chemistry. 75 (24): 8351–8354. doi:10.1021/jo101589h. ISSN 0022-3263.
- Guidelines for solvent purification at UC Davis Archived September 4, 2006, at the Wayback Machine.
- "Drying Solvents". UCDavis Chemwiki. Retrieved 8 April 2014.
- "New Aldrich Sure/Seal® packaging for Anhydrous Solvents and Air-Sensitive Reagents". Sigma-Aldrich. Retrieved 2018-03-26.
- "Drying agents". www.chem.ucla.edu. Retrieved 2018-03-26.