||This article needs more medical references for verification or relies too heavily on primary sources. (February 2010)|
|Trade names||Ampamet, Memodrin, Pergamid|
|AHFS/Drugs.com||International Drug Names|
|Biological half-life||1–2.5 hours|
|Chemical and physical data|
|Molar mass||219.237 g/mol|
|3D model (Jmol)|
|(what is this?)|
Aniracetam (Draganon, Sarpul, Ampamet, Memodrin, Referan), also known as N-anisoyl-2-pyrrolidinone, is an ampakine compound of the racetam chemical class. It is sold in Europe as a prescription drug, but it is not approved by the Food and Drug Administration for use in the United States.
When ingested orally aniracetam is quickly broken down via first pass hepatic metabolism. The primary metabolites of aniracetam are N-anisoyl-GABA, (70–80%), 2-Pyrrolidinone and p-anisic acid (20–30%).
Plasma concentrations are generally in the 5–15 μg/L range for aniracetam and 5–15 mg/L range for N-anisoyl-GABA, a pharmacologically-active metabolite, during the first few hours after oral administration of the drug. These two plasma species may be measured by liquid chromatography-mass spectrometry.
The drug was first made in the 1970s by Hoffmann-La Roche.[full citation needed][full citation needed] Synthesis can be accomplished by reacting 2-pyrrolidone with anisoyl chloride in the presence of triethylamine.
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