Fisher-Wirth is the daughter of a career Army officer and an English teacher. She was born in Washington, D. C., and lived as a child in Germany, Pennsylvania, and Japan before her father retired from the Army and her parents decided to move to Berkeley, California. She earned a B.A. degree, magna cum laude, in English from Pomona College in 1968; an M.A. degree in English and American literature from Claremont Graduate School in 1972; and a Ph.D. in English and American literature from Claremont Graduate School in 1981. Her scholarly work has concentrated primarily on William Carlos Williams and Willa Cather, but she has published on other writers including Cormac McCarthy, Louise Gluck, Robert Hass, and Anita Brookner. She has served as President of the international Association for the Study of Literature and Environment (ASLE), has had a senior Fulbright to the University of Fribourg, Switzerland, and has held the Fulbright Distinguished Chair at Uppsala University, Sweden. She has been teaching at the University of Mississippi since 1988. She has won several teaching awards, including Liberal Arts Outstanding Teacher of the Year (2006), Humanities Teacher of the Year (2007), and the Elsie M. Hood Award (2014). Her poetry has received numerous awards, including several Pushcart nominations and a Pushcart Special Mention. She is married to Peter Wirth. Her daughter, Jessica Fisher, is also a poet.
- The Bones of Winter Birds, Terrapin Press (2019)
- Mississippi, poems by Ann Fisher-Wirth and photographs by Maude Schuyler Clay, Wings Press (2018)
- First, earth, The Chapbook (2015)
- The Ecopoetry Anthology, coedited with Laura-Gray Street, Trinity University Press (2013)
- Dream Cabinet, Wings Press (2012)
- Carta Marina, Wings Press (2009)
- Slide Shows, Finishing Line Press (2009)
- Five Terraces, Wind Publications (2005)
- Walking Wu-Wei's Scroll, Drunken Boat (2005)
- Blue Window, Archer Books (2003)
- The Trinket Poems, Wind Publications (2003)
- William Carlos Williams and Autobiography: The Woods of His Own Nature, Penn State University Press (1989)
Selected honors and awards
- The Elsie M. Hood Outstanding Teaching Award, University of Mississippi (2014)
- Finalist, Poet Laureate of Mississippi (2012)
- University of Mississippi Humanities Teacher of the Year (2007)
- University of Mississippi Liberal Arts Outstanding Teacher of the Year (2006)
- President, Association for the Study of Literature and Environment (2006)
- Literary Artist Fellowship for poetry from the Mississippi Arts Commission (2005)
- Writing Residency, Djerassi Resident Artists Program in Woodside, Calif. (2005)
- Mississippi Institute of Arts and Letters Poetry Award (2004)
- Rita Dove Poetry Award from the Salem College Center for Women Writers (2004)
- Malahat Review Long Poem Prize (2003)
- Fulbright Distinguished Chair of American Studies, Uppsala University, Sweden (2003) 
- Literary Artist Fellowship for poetry from the Mississippi Arts Commission (1998)
- Fulbright Lecturer in American Literature, University of Fribourg, Switzerland (1994)
- "Ann Fisher-Wirth". University of Mississippi–M.F.A. English. Archived from the original on 2016-03-08. Retrieved 4 March 2016.
- "Ann Fisher-Wirth". Black Earth Institute. Retrieved 4 March 2016.
- "Q&A With Ann Fisher-Wirth". Bloom: “Late” according to whom?. March 25, 2015. Retrieved 4 March 2016.
- "Ann Fisher-Wirth Teacher of the Year". The University of Mississippi – College of Liberal Arts. Retrieved 7 March 2016.
- "Dr. Ann Fisher-Wirth". Association of Writers and Writing Programs. Retrieved 7 March 2016.
- "English professor, poet Ann Fisher-Wirth awarded state arts commission grant". The Mississippi Writers Page. Retrieved 7 March 2016.
- "Mississippi Institute of Arts and Letters". Mississippi Institute of Arts and Letters. Archived from the original on 3 March 2016. Retrieved 7 March 2016.
- "Arts Commission News". Mississippi Arts Commission. Archived from the original on 8 March 2016. Retrieved 7 March 2016.