Anna was the daughter of Manuel Angelos Philanthropenos, Caesar of the Byzantine Empire and governor of Thessaly. Manuel ruled Thessaly from c. 1390 until it was conquered by Bayezid I of the Ottoman Empire in 1394.
Her paternal grandfather, or more likely uncle, was Alexios Angelos Philanthropenos, also a Caesar, who was governor of Thessaly from c. 1373 to 1390. Her maternal grandmother, or more likely aunt-in-law, was Maria Radoslava.
Gulkhan-Eudokia of Georgia, Manuel's first wife and Empress consort of Trebizond died 2 May 1395. On 4 September of that year, Eudokia, Manuel's sister and the widow of Tadjeddin Pasha of Sinop and Emir of Limnia, arrived from Constantinople at Kordyle with Anna Philanthropene and Theodora Kantakouzene; these women had come to wed, respectively Manuel III and her nephew Alexios. The combined wedding took place the following day in Trebizond.
The ambassador to Tamerlane, Ruy Gonzáles de Clavijo met Manuel III and his family April 1404 while passing through Trebizond, and alludes to Anna Philanthropene as being alive. Manuel died on 5 March 1417; whether Anna survived him is unknown. Thierry Ganchou claims to have identified a son of Manuel and Anna, who was alive as late as 1423, and old enough to marry Eudokia, the daughter of the protostrator Manuel Palaiologos Kantakouzenos.
- William Miller, Trebizond: The last Greek Empire of the Byzantine Era: 1204-1461, 1926 (Chicago: Argonaut, 1969), p. 72
- Cawley, Charles, Profile of the Philanthropenos family, Medieval Lands database, Foundation for Medieval Genealogy,[better source needed]
- Michael Panaretos, Chronicle, 48. Greek text in Original-Fragmente, Chroniken, Inschiften und anderes Materiale zur Geschichte des Kaiserthums Trapezunt, part 2; in Abhandlungen der historischen Classe der königlich bayerischen Akademie 4 (1844), abth. 1, p. 54; German translation, p. 68
- Panaretos, Chronicle, 55. Greek text in Original-Fragmente, p. 40; German translation, p. 68
- Thierry Ganchou, "A propos d'un cheval de race: un dynaste de Trebizonde en exil a Constantinople au debut du XVe siècle," Mare et Litora: Essays Presented to Sergei Karpov for his 60th Birthday, edited by Rustam Shukurov, (Moscow: Indrik, 2009), pp. 553-575
- Cawley, Charles, Profile of Alexios III and his children, Medieval Lands database, Foundation for Medieval Genealogy
Gulkhan-Eudokia of Georgia
|Empress consort of Trebizond