Anne O'Garra

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Anne O'Garra
FRS FMedSci
Anne O'Garra (cropped).jpg
Born 1954 (age 63–64)
Website www.crick.ac.uk/research/a-z-researchers/researchers-k-o/anne-o%E2%80%99garra/

Anne O'Garra FRS FMedSci (born 1954)[1] is a British immunologist who has made important discoveries on the mechanism of action of Interleukin 10.[2][3]

Early life and education[edit]

O'Garra was born in Gibraltar. From 1977 to 1980, she studied at Chelsea College, University of London, and graduated with a B.Sc. (First Class Honours) in Microbiology and Biochemistry.[4]

Biography[edit]

She received her bachelor's degree in microbiology and biochemistry at the University of London. At the NIMR, she earned her Ph.D. in microbiology, staying on there for a four-year post-doctorate in immunology.

In 1987, O'Garra left England for Palo Alto, California, to work for the DNAX Research Institute, where by 2000 she had become a principal staff scientist in the department of immunobiology.[5] In 2001, O'Garra became the Head of the Division of Immunoregulation at the MRC National Institute for Medical Research (NIMR) in London.[6] Since 2015, she is Associate Research Director at the Francis Crick Institute, the successor institute to the NIMR.

Research[edit]

O'Garra is known for her contributions to the understanding of the intricate network of cell-cell and cytokine interactions regulating the induction and suppression of cellular immune responses. She was the first to discover the immunosuppressive functions of Interleukin-10 (IL-10), which inhibits antigen presentation by dendritic cells and macrophages and reduces their production of proinflammatory cytokines. She also discovered that dendritic cells produce the interleukin essential for activation of T-cells (IL-12) and subsequent eradication of intracellular pathogens and that IL-10 regulates this production. [7]

Awards and honors[edit]

She is a fellow of the Royal Society, the American Association for the Advancement of Science (AAAS), and the Academy of Medical Sciences.

References[edit]

  1. ^ "Driving change in tuberculosis research: an interview with Anne O'Garra". Disease Models & Mechanisms. 6 (1): 6–8. 24 December 2012. doi:10.1242/dmm.011429. 
  2. ^ Anne O'Garra Profile
  3. ^ Moore, Kevin W.; de Waal Malefyt, Rene; Coffman, Robert L.; O'Garra, Anne (2001). "INTERLEUKIN-10AND THEINTERLEUKIN-10 RECEPTOR". Annual Review of Immunology. 19 (1): 683–765. doi:10.1146/annurev.immunol.19.1.683. ISSN 0732-0582. PMID 11244051. 
  4. ^ "Profile Anne O'Garra" (PDF). ENII. Retrieved 29 July 2013. 
  5. ^ "ScienceWatch". 
  6. ^ "National Institute for Medical Research". Archived from the original on September 17, 2009. Retrieved July 19, 2010. 
  7. ^ "Royal Society New Fellows 2008".