Annexin A3

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Protein ANXA3 PDB 1aii.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesANXA3, ANX3, annexin A3
External IDsMGI: 1201378 HomoloGene: 68445 GeneCards: ANXA3
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ANXA3
Genomic location for ANXA3
Band4q21.21Start78,551,519 bp[1]
End78,610,451 bp[1]
RNA expression pattern
PBB GE ANXA3 209369 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 4: 78.55 – 78.61 MbChr 5: 96.79 – 96.85 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.[5][6]

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.[7]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138772 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029484 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM (Aug 1991). "Chromosomal localization of the human annexin III (ANX3) gene". Genomics. 10 (2): 441–8. doi:10.1016/0888-7543(91)90330-H. PMID 1830024. 
  6. ^ a b "Entrez Gene: ANXA3 annexin A3". 
  7. ^ Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics. 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID 18792929. 

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