Antara Mali was born in Mumbai on 1 July 1979, to a kushwaha family India photographer Jagdish Mali. She is married to Che Kurrien, the editor of GQ magazine since 12 June 2009.
Mali's father had a history of diabetes and other illness. On being contacted after he was reported found disoriented in the streets, Antara Mali claimed that she was not in a position to take responsibility for her parent as she was soon to become a mother.
Mali gave birth to a baby girl, on 1 May 2012, at the Breach Candy hospital in Mumbai and refuses to share her personal life in public.
Mali made her acting debut in the 1998 filmDhoondte Reh Jaaoge!. The film, however, flopped. The next year was released her film Prema Katha directed by Ram Gopal Varma. Afterwards, Varma became Mali's frequent collaborator. Although Mali's performances were praised by critics, most of them did not do well at the box office.
She discontinued her acting career in 2005 after her last film Mr Ya Miss (which she had also written and directed) was received poorly and critically panned. Mali paid her tribute to Madhuri Dixit by playing an aspiring actress inspired by Madhuri in the movie Main Madhuri Dixit Banna Chahti Hoon. She received a Filmfare nomination for the Best Actress in a Supporting Role for Company.