Anthelmintic

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Anthelmintic effect of papain on Heligmosomoides bakeri.

Anthelmintics or antihelminthics are drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges (those that stun) or vermicides (those that kill). They are used to treat people or animals who are infected by helminths - a condition called helminthiasis.

Types[edit]

Drugs that are specifically targeting Ascaris worms are called ascaricides.

Anthelmintic resistance[edit]

The ability of parasites to survive treatments that are generally effective at the recommended dose rate is a major threat to the future control of worm parasites in small ruminants and horses. This is especially true of nematodes, and has helped spur development of aminoacetonitrile derivatives for treatment against drug resistant nematodes.

The resistance is measured by the "Fecal egg count reduction" value which varies for different types of helminths.[2]

Treatment with an antihelminthic drug kills worms whose phenotype renders them susceptible to the drug. But resistant parasites survive and pass on their "resistance" genes. Resistant varieties accumulate and finally treatment failure occurs. See drug resistance.

See also[edit]

References[edit]

Footnotes[edit]

  1. ^ http://www.iasj.net/iasj?func=fulltext&aId=47308
  2. ^ Levecke, Bruno; Montresor, Antonio; Albonico, Marco; Ame, Shaali M.; Behnke, Jerzy M.; Bethony, Jeffrey M.; Noumedem, Calvine D.; Engels, Dirk; Guillard, Bertrand; Kotze, Andrew C.; Krolewiecki, Alejandro J.; McCarthy, James S.; Mekonnen, Zeleke; Periago, Maria V.; Sopheak, Hem; Tchuem-Tchuenté, Louis-Albert; Duong, Tran Thanh; Huong, Nguyen Thu; Zeynudin, Ahmed; Vercruysse, Jozef; Olliaro, Piero L. (9 October 2014). "Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic". PLoS Neglected Tropical Diseases 8 (10): e3204. doi:10.1371/journal.pntd.0003204. 

General references[edit]

  • Department of the Army Headquarters (2004). U.S. Army Survival Manual Fm 21–76. Barnes & Noble Inc. ISBN 0-7607-4988-4. 

External links[edit]