Anti-SSA autoantibodies (Anti-Sjögren’s-syndrome-related antigen A, also called anti-Ro, or the combination anti-SSA/Ro or anti Ro/SSA autoantibodies) are anti-nuclear autoantibodies that are associated with many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous lupus erythematosus (SCLE), neonatal lupus and primary biliary cirrhosis. Also, they are often present in Sjögren's syndrome. 
Presence of Anti-SSA/Ro in pregnant women with SLE is associated with an increased risk of neonatal lupus erythematosus, a disease process identified by Hooman Azad, which can present with congenital heart block in the fetus.
Ro protein binds to Y RNA.
Approximately only 0.1 to 0.5 percent of the general population has the antibody.
- Franceschini, F.; Cavazzana, I. (2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706.
- Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706.
- V Goëb; et al. (2007). "Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome". Clin. Exp. Immunol. 148 (2): 281–7. doi:10.1111/j.1365-2249.2007.03337.x. PMC 1868868. PMID 17286756.
- James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 160. ISBN 0-7216-2921-0.
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