Anti-tetanus immunoglobulin

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Anti-tetanus immunoglobulin
Clinical data
Trade namesHyperTET S/D, others
Synonymstetanus immune globulin, tetanus antitoxin
  • US: C (Risk not ruled out)
Routes of
  • none

Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of antibodies against the tetanus toxin.[1] It is used to prevent tetanus in those who have a wound that is at high risk and have not been fully vaccinated with tetanus toxoid.[1] It is also used to treat tetanus along with antibiotics and muscle relaxants.[1] It is given by injection into a muscle.[1]

Common side effects include pain at the site of injection and fever.[1] Allergic reactions including anaphylaxis may rarely occur.[1] There is also a very low risk of the spread of infections such as viral hepatitis and HIV/AIDS with the human version.[1] Use during pregnancy is deemed acceptable.[2] It is made from either human or horse blood plasma.[1][3]

Use of the horse version became common in the 1910s, while the human version came into frequent use in the 1960s.[4] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] The wholesale cost in the developing world for the horse version is about US$0.90–3.60 per 1500 iu vial, while the human version is US$10.00–46.86 for 250 iu.[6][7][8] The human version may be unavailable in the developing world.[3] In the United States a course of treatment costs about $100–200.[9] The horse version is not typically used in the developed world due to the risk of serum sickness.[10]


  1. ^ a b c d e f g h "Tetanus Immune Globulin". The American Society of Health-System Pharmacists. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  2. ^ "Tetanus immune globulin Use During Pregnancy |". Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  3. ^ a b International Encyclopedia of Public Health (2 ed.). Academic Press. 2016. p. 161. ISBN 9780128037089. Archived from the original on 2017-01-09.
  4. ^ Plotkin, Stanley A.; Orenstein, Walter A.; Offit, Paul A. (2012). Vaccines. Elsevier Health Sciences. pp. 103, 757. ISBN 1455700908. Archived from the original on 2017-01-09.
  5. ^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
  6. ^ "Tetanus Antitoxin". International Drug Price Indicator Guide. Retrieved 8 December 2016.
  7. ^ "Immunoglobulin Prices 2013 - PAHO/WHO". PAHO. Archived from the original on 7 June 2016. Retrieved 8 January 2017.
  8. ^ "Immunoglobulin, Anti-Tetanus". International Drug Price Indicator Guide. Retrieved 8 December 2016.
  9. ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 320. ISBN 9781284057560.
  10. ^ Fauci, Anthony S.; Braunwald, Eugene; Kasper, Dennis L.; Hauser, Stephen; Longo, Dan; Jameson, J. Larry; Loscalzo, Joseph (2008). Harrison's Principles of Internal Medicine, 17th Edition. McGraw Hill Professional. p. 773. ISBN 9780071641142. Archived from the original on 2017-01-09.