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An antidote is a substance that can counteract a form of poisoning. The term ultimately derives from the Greek term φάρμακον ἀντίδοτον (pharmakon) antidoton, "(medicine) given as a remedy". Antidotes for anticoagulants are sometimes referred to as reversal agents.
The antidotes for some particular toxins are manufactured by injecting the toxin into an animal in small doses and extracting the resulting antibodies from the host animals' blood. This results in an antivenom that can be used to counteract venom produced by certain species of snakes, spiders, and other venomous animals. Some animal venoms, especially those produced by arthropods (e.g., certain spiders, scorpions, bees, etc.) are only potentially lethal when they provoke allergic reactions and induce anaphylactic shock; as such, there is no "antidote" for these venoms because it is not a form of poisoning and anaphylactic shock can be treated (e.g., by the use of epinephrine).
Some other toxins have no known antidote. For example, the poison aconitine – a highly poisonous alkaloid derived from various aconite species – has no antidote, and as a result, is often fatal if it enters the human body in sufficient quantities.
Ingested poisons are frequently treated by the oral administration of activated charcoal, which adsorbs the poison and flushes it from the digestive tract, thereby removing a large part of the toxin. Poisons which are injected into the body (such as those from bites or stings from venomous animals) are usually treated by the use of a constriction band which limits the flow of lymph and/or blood to the area, thus slowing the circulation of the poison around the body. This should not be confused with the use of a tourniquet which cuts off blood flow completely - often leading to the loss of the limb.
List of antidotes
|Look up antidote in Wiktionary, the free dictionary.|
- "antidote" at Dorland's Medical Dictionary .
- Christos S, Naples R (2016). "Anticoagulation Reversal and Treatment Strategies in Major Bleeding: Update 2016". West J Emerg Med. 17: 264–70. doi:10.5811/westjem.2016.3.29294. PMC 4899056. PMID 27330657.
- "Calcium channel blocker poisoning". UpToDate. Retrieved 2019-07-09.